FLOW VELOCITY MAPPING USING CONTRAST ENHANCED HIGH-FRAME-RATE PLANE WAVE ULTRASOUND AND IMAGE TRACKING: METHODS AND INITIAL IN VITRO AND IN VIVO EVALUATION
FLOW VELOCITY MAPPING USING CONTRAST ENHANCED HIGH-FRAME-RATE PLANE WAVE ULTRASOUND AND IMAGE TRACKING: METHODS AND INITIAL IN VITRO AND IN VIVO EVALUATION
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DOI：
10.1016/j.ultrasmedbio.2015.06.012
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发表时间：
2015-11-01
影响因子：
2.9
通讯作者：
Tang, Meng-Xing
中科院分区：
文献类型：
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作者：
Leow, Chee Hau;Bazigou, Eleni;Tang, Meng-Xing
超声成像是医学实践中应用最广泛的血流可视化和定量方法，但现有技术在成像灵敏度、视场、血流角度依赖性和成像深度等方面存在各种局限性。在这项研究中，我们通过结合高帧率平面波超声成像、微泡造影剂、脉冲反转造影剂和散斑图像跟踪算法，开发了一种能够可视化和量化动态血流的超声成像测速方法。该系统最初在体外对具有稳定和脉动流动的直血管和颈动脉模拟血管以及兔主动脉的体内进行了评估。还进行了彩色和光谱多普勒测量。将初始流图结果与理论预测和参考多普勒测量结果进行了比较，表明新系统作为一种高灵敏度、精确、不依赖角度和全视场速度图工具的潜力，能够跟踪和量化快速和动态的流。（E-mail: mengxing.tang@imperial.ac.uk） (C) 2015世界超声医学与生物学联合会。
Ultrasound imaging is the most widely used method for visualising and quantifying blood flow in medical practice, but existing techniques have various limitations in terms of imaging sensitivity, field of view, flow angle dependence, and imaging depth. In this study, we developed an ultrasound imaging velocimetry approach capable of visualising and quantifying dynamic flow, by combining high-frame-rate plane wave ultrasound imaging, microbubble contrast agents, pulse inversion contrast imaging and speckle image tracking algorithms. The system was initially evaluated in vitro on both straight and carotid-mimicking vessels with steady and pulsatile flows and in vivo in the rabbit aorta. Colour and spectral Doppler measurements were also made. Initial flow mapping results were compared with theoretical prediction and reference Doppler measurements and indicate the potential of the new system as a highly sensitive, accurate, angle-independent and full field-of-view velocity mapping tool capable of tracking and quantifying fast and dynamic flows. (E-mail: mengxing.tang@imperial.ac.uk) (C) 2015 World Federation for Ultrasound in Medicine & Biology.