Basal forebrain lesions alter stimulus-evoked metabolic activity in rat somatosensory cortex

Basal forebrain lesions alter stimulus-evoked metabolic activity in rat somatosensory cortex
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基底前脑损伤改变大鼠体感皮层刺激诱发的代谢活动

DOI:
10.1016/0006-8993(91)91256-z
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发表时间:
1991
期刊:
影响因子:
2.9
通讯作者:
S. Juliano
S. Juliano
中科院分区:
医学3区
文献类型:
--
作者:
S. E. Jacobs;R. A. Code;S. Juliano

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乙酰胆碱(ACh)被认为在正常的皮质功能中起着至关重要的作用。为探讨皮层ACh耗竭对大鼠躯体感觉皮层桶形野代谢活动的影响,本实验采用单侧损毁大鼠基底前脑的方法。1~9周后进行2-脱氧葡萄糖实验。与对侧相比,损伤同侧桶状野中刺激诱发的代谢活性显著降低。这些结果表明,ACh在处理刺激诱发的感觉信息中起着重要作用。
Acetylcholine (ACh) has been suggested to play a crucial role in normal cortical functioning. To assess the impact of cortical ACh depletion on metabolic activity in the barrel field of rat somatosensory cortex, unilateral lesions of the basal forebrain were made. One to 9 weeks later, a 2-deoxyglucose experiment was conducted. Stimulus-evoked metabolic activity in the barrel field ipsilateral to the lesion was significantly reduced compared with the contralateral side. These results suggest that ACh plays a significant role in processing stimulus-evoked sensory information.
DOI: --
发表时间: 1985
期刊: Biomedical sciences instrumentation
影响因子: --
作者:
Tommerdahl,M;Baker,R;Whitsel,B;Juliano,S
通讯作者: Juliano,S
乙酰胆碱对猫体感皮层神经元反应特性的影响。
DOI: 10.1152/jn.1988.59.4.1231
发表时间: 1988
影响因子: 2.5
作者:
Metherate,R;Tremblay,N;Dykes,RW
通讯作者: Dykes,RW
乙酰胆碱对猫体感皮层神经元反应性的短暂和长期影响。
DOI: 10.1152/jn.1988.59.4.1253
发表时间: 1988
影响因子: 2.5
作者:
Metherate,R;Tremblay,N;Dykes,RW
通讯作者: Dykes,RW