Plasma Vitamin D Biomarkers and Leukocyte Telomere Length
Plasma Vitamin D Biomarkers and Leukocyte Telomere Length
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DOI：
10.1093/aje/kws435
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发表时间：
2013-06-15
影响因子：
5
通讯作者：
De Vivo, Immaculata
中科院分区：
文献类型：
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作者：
Liu, Jason J.;Prescott, Jennifer;De Vivo, Immaculata
维生素D可以通过抗炎和抗细胞增殖机制减少端粒缩短。在本研究中，我们通过使用血浆25-羟基维生素D（25（OH）D）和1，25-二羟基维生素D（1，25（OH）（2）D）生物标志物来检查维生素D和相对白细胞端粒长度之间的关联。维生素D生物标志物水平和白细胞端粒长度的测量使用的血浆样本收集于1989 - 1990年的护士健康研究，研究护士来自美国11个州。总共有1，424名参与者接受了25（OH）D水平评估，837名参与者接受了1，25（OH）（2）D水平评估。对480名参与者进行了维生素D相关基因12个单核苷酸多态性的基因分型。使用线性和logistic回归模型。较高的25（OH）D水平与较长的端粒长度显著相关（趋势P <0.05），比值比从25（OH）D第二低四分位数与最低四分位数比较时的1.07（P <0.65）增加到最高四分位数与最低四分位数比较时的1.59（P <0.01）。维生素D相关的单核苷酸多态性和1，25（OH）（2）D水平与端粒长度无显著相关。总钙摄入量显着修改之间的关联25（OH）D和端粒长度（P的相互作用0.05）。较高的血浆25（OH）D水平可能与较长的端粒相关，这种相关性可能通过钙的摄入来改变。
Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) biomarkers. Vitamin D biomarker levels and leukocyte telomere length were measured using plasma samples collected in 19891990 from participants of the Nurses Health Study, a study of nurses from 11 US states. In total, 1,424 participants had their 25(OH)D levels assessed and 837 had their 1,25(OH)(2)D levels assessed. Genotyping was performed on 480 participants on 12 single nucleotide polymorphisms in vitamin Drelated genes. Linear and logistic regression models were used. Higher 25(OH)D levels were significantly associated with longer telomere length (P for trend 0.05), and the odds ratio increased from 1.07 (P 0.65) when comparing the second lowest quartile of 25(OH)D with the lowest to 1.59 (P 0.01) when comparing the highest quartile with the lowest. Vitamin Drelated single nucleotide polymorphisms and 1,25(OH)(2)D levels were not significantly associated with telomere length. Total calcium intake significantly modified the association between 25(OH)D and telomere length (P for interaction 0.05). Higher plasma 25(OH)D levels may be associated with longer telomeres, and this association may be modified by calcium intake.