Effect of metoprolol on the submaximal stress test performed early after acute myocardial infarction.
Effect of metoprolol on the submaximal stress test performed early after acute myocardial infarction.
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美托洛尔对急性心肌梗死后早期进行的次最大应激试验的影响。
DOI：
10.1016/0002-9149(87)90333-x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. LaMountain
中科院分区：
文献类型：
--
作者：
P. Ades;James D. Thomas;John S. Hanson;Stanley M. Shapiro;J. LaMountain
为了确定β-肾上腺素能阻断剂对急性心肌梗死（AMI）后亚极大负荷测试的影响，36例AMI后患者在使用和不使用美托洛尔的情况下进行了2天的跑步机测试，这是一项双盲、安慰剂对照、交叉设计研究。与安慰剂相比，每天两次给予100mg美托洛尔可降低休息和峰值次最大运动心率（从84±3到68±2次/分钟，p < 0.001，从126±3到97±2次/分钟，p < 0.001）。静息和亚峰值收缩压也有所下降（从121±3降至108±2 mm Hg， p < 0.001，从151±4降至124±3 mm Hg， p < 0.001）。在12名服用安慰剂的患者中，运动引起的st段较基线下降1mm或更多。而服用美托洛尔运动时，仅有4例患者出现ST区抑郁（p < 0.05）。4例服用安慰剂的患者发生心绞痛，但其中只有1例服用β阻断药物。由此得出结论，β阻断治疗使ami后亚极大应激测试对运动引起的缺血标志物的敏感性低于不使用该药物的测试。因此，在使用已发表研究的预后信息时，确定运动试验的条件是很重要的。
To determine the effect of β-adrenergic blockade on the submaximal stress test after acute myocardial infarction (AMI), 36 post-AMI patients performed their treadmill test on 2 separate days, with and without metoprolol, in a double-blind, placebo-controlled, crossover design study. Rest and peak submaximal exercise heart rate was diminished by 100 mg of metoprolol administered twice daily (from 84 ± 3 to 68 ± 2 beats/min, p < 0.001, and from 126 ± 3 to 97 ± 2 beats/min, p < 0.001, respectively) compared with placebo. Rest and peak submaximal systolic blood pressure was also decreased (from 121 ± 3 to 108 ± 2 mm Hg, p < 0.001, and from 151 ± 4 to 124 ± 3 mm Hg, p < 0.001). Exercise-induced ST-segment depression of 1 mm or more from baseline occurred in 12 patients taking placebo. However, only 4 of these patients had ST depression when they exercised while taking metoprolol (p < 0.05). Angina pectoris occurred in 4 patients taking placebo but in only 1 of these taking a β-blocking drug. It is concluded that β-blocking therapy renders the post-AMI submaximal stress test less sensitive for markers of exercise-induced ischemia than if the test is performed without the drug. Therefore, when using the prognostic information of published studies, it is important to define the conditions surrounding the exercise test.
心肌梗塞后不久进行有限的运动测试。
影响因子：
39.2
作者：
Schwartz,KM;Turner,JD;Sheffield,LT;Roitman,DI;Kansal,S;Papapietro,SE;Mantle,JA;Rackley,CE;RussellJr,RO;Rogers,WJ
通讯作者：
Rogers,WJ