Prolactin and growth hormone release by morphine in the rat: different receptor mechanisms.
Prolactin and growth hormone release by morphine in the rat: different receptor mechanisms.
复制标题
大鼠吗啡释放催乳素和生长激素：不同的受体机制。
DOI：
10.1126/science.6285470
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Pasternak,GW
中科院分区：
文献类型：
--
作者：
Spiegel,K;Kourides,IA;Pasternak,GW
吗啡显着增加大鼠血清中催乳素和生长激素的浓度。剂量反应研究表明，最大催乳素释放所需的吗啡剂量低于最大生长激素反应所需的吗啡剂量。用不可逆拮抗剂纳洛沙宗选择性阻断 μ1（高亲和力）阿片受体，可使吗啡诱导的催乳素峰值浓度降低 80%，同时使生长激素峰值水平提高 250%。这些结果表明阿片类药物调节两种激素的受体机制不同。 μ1（高亲和力）受体位点似乎介导吗啡诱导的催乳素释放，但不介导生长激素的释放。
Concentrations of prolactin and growth hormone in the serum of rats were significantly increased by morphine. Dose response studies demonstrated that maximum prolactin release required lower doses of morphine than those needed for the maximum growth hormone response. Selective blockade of μ1(high affinity) opiate receptors with the irreversible antagonist naloxazone reduced morphine-induced peak concentrations of prolactin by 80 percent while increasing peak growth hormone levels by 250 percent. These results suggest different receptor mechanisms for the opiate modulation of the two hormones. The μ1(high affinity) receptor sites appear to mediate the morphine-induced release of prolactin but not growth hormone.