Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome
Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome
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DOI：
10.1038/mp.2015.29
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发表时间：
2016-02-01
影响因子：
11
通讯作者：
Lipkin, W. I.
中科院分区：
文献类型：
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作者：
Hornig, M.;Gottschalk, G.;Lipkin, W. I.
肌痛性脑脊髓炎/慢性疲劳综合征是一种原因不明的衰弱障碍，经常与认知和运动功能障碍有关。我们分析了32例患者，40例多发性硬化症患者和19名年龄和性别频率匹配的正常人的脑脊液，采用51-plex细胞因子分析。在大多数分析物中发现了特定于组的差异，CCL11(嗜酸性粒细胞趋化因子)的病例增加，这是一种参与嗜酸性粒细胞招募的趋化因子。网络分析显示，白细胞介素1受体拮抗剂与集落刺激因子1、集落刺激因子2和白细胞介素17F呈负相关，对白细胞介素1α和β无影响，提示白细胞介素1信号转导紊乱。我们的结果表明，病例脑脊液中的免疫信号明显紊乱，这与中枢神经系统的免疫激活一致，并转向与自身免疫相关的过敏或T辅助细胞2型模式。
Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cytokine assay. Group-specific differences were found for the majority of analytes with an increase in cases of CCL11 (eotaxin), a chemokine involved in eosinophil recruitment. Network analysis revealed an inverse relationship between interleukin 1 receptor antagonist and colony-stimulating factor 1, colony-stimulating factor 2 and interleukin 17F, without effects on interleukin 1 alpha or interleukin 1 beta, suggesting a disturbance in interleukin 1 signaling. Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity.