Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction
Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction
复制标题
甲状腺功能正常的急性心肌梗死受试者中游离三碘甲状腺原氨酸水平与国际标准化比值呈负相关
DOI：
10.1038/aps.2011.118
复制
发表时间：
2011-11-01
影响因子：
8.2
通讯作者：
Yang, Zhi-jian
中科院分区：
文献类型：
--
作者：
Li, Li;Guo, Chang-yan;Yang, Zhi-jian
目的：探讨甲状腺功能正常的急性ST段抬高型心肌梗死（STEMI）患者血清游离三碘甲状腺原氨酸（FT 3）水平与国际标准化比值（患者凝血酶原时间与正常人的比值，INR）的关系。收集所有患者的人体测量和实验室测量结果，包括心率、呼吸频率、血压、体温、血小板计数、INR、凝血酶原时间、活化部分凝血活酶时间、FT 3、游离甲状腺素（FT 4）和促甲状腺激素。采用全自动免疫分析仪测定血清FT 3、FT 4水平。结果：按FT 3、FT 4四分位数分为4组：FT 3 0.40-3.09（n= 52）、3.10-3.69（n= 56）、3.70-4.29（n= 64）、4.30-7.10（n= 59）; FT 4为4.9-14.8（n= 57）、14.9-16.8（n= 58）、16.9-18.7（n= 57）和18.8-29.0（n= 59）。FT 3水平高的受试者INR值显著低于FT 3水平低的受试者（P= 0.01）。多元线性回归分析显示，血清FT 3降低是INR升高的独立危险因素（β=-0.139，P = 0.025）。结论：在甲状腺功能正常的急性STEMI患者中，游离三碘甲状腺原氨酸与INR呈负相关。
Aim:To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI).Methods:A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer.Results:Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40–3.09 (n= 52), 3.10–3.69 (n= 56), 3.70–4.29 (n= 64) and 4.30–7.10 (n= 59) for FT3; 4.9–14.8 (n= 57), 14.9–16.8 (n= 58), 16.9–18.7 (n= 57) and 18.8–29.0 (n= 59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P= 0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P= 0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P= 0.36).Conclusion:Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function.