Outcome of patients with nonstenotic, nonfistulizing Crohn's disease
Outcome of patients with nonstenotic, nonfistulizing Crohn's disease
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DOI：
10.1007/s10620-004-9568-1
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发表时间：
2004-11-01
影响因子：
3.1
通讯作者：
Ponce, J
中科院分区：
文献类型：
--
作者：
Nos, P;Garrigues, V;Ponce, J
克罗恩病的非狭窄、非瘘管化（或炎症）模式在时间上似乎不稳定，可能向狭窄或瘘管化模式发展。我们的目的是评估炎症性疾病的病程及其与某些临床特征的关系。在平均随访93个月后，我们评估了73例有炎症模式的患者。分析其行为趋势及其与疾病部位、初始治疗、是否需要皮质类固醇、免疫抑制剂和手术切除的关系。在64%的患者中，炎症模式没有改变，而在14%和22%的患者中，炎症模式分别演变为狭窄和瘘管模式。这种改变主要是由肛周疾病的出现决定的（75%）。行为进化的平均时间为67个月。大多数患者需要皮质类固醇（92%）。需要免疫抑制剂（48%）和手术切除（30%）的患者显著增加(P
The nonstenotic, nonfistulizing (or inflammatory) pattern of Crohn's disease appears to be unstable in time and may evolve toward either the stenotic or the fistulizing pattern. We aimed to assess the course of the inflammatory disease and its relation to certain clinical characteristics. After a mean follow-up of 93 months, we evaluated 73 patients with an inflammatory pattern. The behavior trend and its relation to disease location, initial treatment, and need for corticosteroids, immunosuppressors, and surgical resection were analyzed. In 64% of the patients the inflammatory pattern did not change, while in 14 and 22% it evolved toward a stenotic and a fistulizing pattern, respectively. This change was mainly determined by the appearance of perianal disease (75%). The mean time to behavior evolution was 67 months. Most patients required corticosteroids (92%). Need for immunosuppressors (48%) and surgical resection (30%) was significantly greater (P