A role for ferrous ion and oxygen in the degradation of DNA by bleomycin.
A role for ferrous ion and oxygen in the degradation of DNA by bleomycin.
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亚铁离子和氧在博来霉素降解 DNA 中的作用。
DOI：
10.1016/0006-291x(76)90882-2
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发表时间：
1976
影响因子：
3.1
通讯作者：
S. Horwitz
中科院分区：
文献类型：
--
作者：
E. Sausville;J. Peisach;S. Horwitz
博莱霉素和低浓度的Fe（II）的DNA降解之间的相互作用的报告。当Fe（II）、博莱霉素和DNA的摩尔浓度大致相等时，猿猴病毒40 DNA完全转化为酸溶性产物;在此反应中，Fe（III）不能取代Fe（II）。厌氧抑制博莱霉素和Fe（II）所观察到的DNA降解。光谱研究表明，博莱霉素和Fe（II）之间形成的氧不稳定的络合物。
An interaction between bleomycin and low concentrations of Fe(II) in the degradation of DNA is reported. Complete conversion of simian virus 40 DNA to acid-soluble products occurs at approximately equimolar levels of Fe(II), bleomycin, and DNA; Fe(III) does not substitute for Fe(II) in this reaction. Anaerobiosis inhibits the observed DNA degradation by bleomycin and Fe(II). Optical spectral studies reveal that an oxygen-labile complex is formed between bleomycin and Fe(II).