Antibody Response for L1, E6, E7 HPV 16, and HPV 18 Antigens in Tunisian Women with Cervical Cancer
Antibody Response for L1, E6, E7 HPV 16, and HPV 18 Antigens in Tunisian Women with Cervical Cancer
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DOI：
10.1080/15321810802569543
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Oueslati, R.
中科院分区：
文献类型：
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作者：
Achour, M.;Zeghal, D.;Oueslati, R.
结果表明，Luminex法比ELISA法更敏感。ELISA检测宫颈癌患者对早期抗原E6和E7的反应性为37%，对HPV 16为42%，对HPV 18为21%，对HPV 18为20%。然而，当使用Luminex技术时，E6和E7 HPV 16的比例分别为44%和61%，而E6和E7 HPV 18的比例分别为28%和21%。数据还表明，HPV 16和HPV 18在不同抗原检测中表现出不同的特征。宫颈癌与良性病例对不同抗原的抗体反应差异有统计学意义。
Results obtained in the present work indicated that the Luminex assay is more sensitive than ELISA. The reactivity to the early antigens E6 and E7 was 37% versus 42% for HPV 16 and 21% versus 20% for HPV 18 among cervical cancer cases using ELISA. However, these ratios were 44% and 61%, respectively, for E6 and E7 HPV 16 versus 28% and 21% for E6 and E7 HPV 18 when using the Luminex technique. Data also indicated that HPV 16 and HPV 18 showed distinct profiles for the different antigens tested. Finally, the differences in antibody responses between cervical cancer cases and benign cases toward the different antigens were significant.