Preliminary findings from a study of first-episode psychosis in Montreal, Canada and Chennai, India: Comparison of outcomes
Preliminary findings from a study of first-episode psychosis in Montreal, Canada and Chennai, India: Comparison of outcomes
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DOI：
10.1016/j.schres.2010.05.032
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发表时间：
2010-08-01
影响因子：
4.5
通讯作者：
Malla, Ashok K.
中科院分区：
文献类型：
--
作者：
Iyer, Srividya N.;Mangala, Ramamurti;Malla, Ashok K.
背景资料：本文报告了在加拿大和印度两个类似结构的治疗方案中，对先前未经治疗的首发精神病的发病和病程进行多年调查的初步结果。具体来说，本研究的目的是检查是否一年的临床和功能性结果的首发精神病不同这两个程序。方法：对在印度钦奈（N = 61）和加拿大蒙特利尔（N = 88）接受类似治疗的首发非情感性精神病患者的人口统计学变量、未治疗精神病的持续时间和基线诊断进行了评价，阴性，一般精神病理学症状和整体功能在基线和一year.Results：在这两个网站，有一个显着的改善症状和功能超过一年的治疗过程。在控制年龄、性别和婚姻状况后，阴性症状和功能也存在显着的逐地点相互作用。在这些领域，印度患者随着时间的推移比加拿大患者表现出更大的改善。的时间由网站的相互作用是不显着的阳性症状和一般psychopathology.Conclusion：在印度的程序中的首发患者表现出较高的改善率在一年内的阴性症状和功能比患者接受类似的治疗在加拿大。阳性症状和一般精神病理学的改善之间没有差异。这些结果表明，社会文化背景下的治疗可以影响结果的早期精神障碍的过程中。此外，在一种社会文化背景下，与另一种社会文化背景相比，结果并不总是更好或更差，而是似乎因结果领域而异。(C)2010爱思唯尔有限公司版权所有。
Background: This article reports preliminary findings from a multi-year investigation of onset and course of previously untreated first-episode psychosis in two similarly structured treatment programs in Canada and India. Specifically, the aim of this study was to examine whether one year clinical and functional outcomes of first-episode psychosis varied between these two programs.Method: Patients with first-episode non-affective psychosis receiving similar treatment in Chennai, India (N = 61) and in Montreal, Canada (N = 88) were evaluated for demographic variables, duration of untreated psychosis, and baseline diagnosis, and for positive, negative, and general psychopathology symptoms and overall functioning at baseline and one year.Results: At both sites, there was a significant improvement in symptoms and functioning over the one year course of treatment. There was also a significant time-by-site interaction on negative symptoms and functioning, after controlling for age, sex, and marital status. On these domains, patients in India showed greater improvement over time than their Canadian counterparts. The time-by-site interactions were not significant for positive symptoms and general psychopathology.Conclusion: First-episode patients in the Indian program demonstrated higher rates of improvement at one year in negative symptoms and functioning than patients receiving similar treatment in Canada. There was no difference in improvement between the sites on positive symptoms and general psychopathology. These results suggest that the sociocultural context of treatment can influence outcomes early in the course of psychotic disorders. Further, outcomes are not uniformly better or worse in one sociocultural context compared to another, but seem to vary from one outcome domain to another. (C) 2010 Elsevier B.V. All rights reserved.