Human morbid genetics revisited: relevance of epigenetics
Human morbid genetics revisited: relevance of epigenetics
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DOI：
10.1016/s0168-9525(00)02213-7
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发表时间：
2001-03-01
影响因子：
11.4
通讯作者：
Petronis, A
中科院分区：
文献类型：
--
作者：
Petronis, A
鉴定使其携带者易患复杂疾病的基因是一项比寻找与简单孟德尔疾病有关的基因复杂得多的任务。复杂疾病的基因研究进展缓慢，可能是由于基础研究战略的局限性，这几乎完全是面向检测与疾病有关的DNA突变或多态性。我认为，在这篇文章中，表观遗传失调的基因是更符合复杂的疾病的特征比DNA序列变异，因此，表观遗传因素可能是重要的，在了解复杂的疾病的起源。
Identification of genes predisposing their carrier to complex diseases is a much more complicated task than finding genes involved in simple mendelian diseases. The slow progress in the genetic research of complex diseases could be due to limitations in the basic research strategy, which is almost exclusively orientated to the detection of disease-related DNA mutations or polymorphisms. I argue in this article that epigenetic misregulation of genes is more consistent with the features of complex diseases than is DNA sequence variation, and therefore that epigenetic factors could be important in understanding the origins of complex diseases.