Use of S-LANSS, a Tool for Screening Neuropathic Pain, for Predicting Postherpetic Neuralgia in Patients After Acute Herpes Zoster Events: A Single-Center, 12-Month, Prospective Cohort Study
Use of S-LANSS, a Tool for Screening Neuropathic Pain, for Predicting Postherpetic Neuralgia in Patients After Acute Herpes Zoster Events: A Single-Center, 12-Month, Prospective Cohort Study
复制标题
DOI：
10.1016/j.jpain.2013.10.006
复制
发表时间：
2014-02-01
期刊：
影响因子：
4
通讯作者：
Kim, Hye One
中科院分区：
文献类型：
--
作者：
Cho, Soo Ick;Lee, Cheol Heon;Kim, Hye One
带状疱疹后神经痛（PHN）是带状疱疹事件最严重的后遗症之一。据报道，PHN 的几个危险因素包括年老、严重皮疹和剧烈疼痛。因此，本研究旨在评估自我完成的利兹神经病理性症状和体征疼痛量表 (S-LANSS) 与之前报道的预测 PHN 风险因素的有用性。队列研究中纳入了一组带状疱疹患者（N = 305）。询问受试者的人口统计信息、临床症状和体征、视觉模拟量表 (VAS) 的疼痛强度和 S-LANSS。他们通过临床访问或电话进行了为期 12 个月的随访。本研究中 19 名患者（6.2%）患有 PHN。使用逻辑回归，确定了 PHN 的 3 个危险因素：年龄 >= 70 岁、高 VAS 评分和高 S-LANSS 评分。使用 VAS (>= 8) 和 S-LANSS (>= 15) 标准预测 PHN 的敏感性为 78.9%，特异性为 78.0%。使用 VAS (>= 6) 和 S-LANSS (>= 15) 标准预测老年患者 (>= 70 岁) PHN 的敏感性为 100%，特异性为 57.1%。 S-LANSS 可能是 PHN 的有用预测工具，特别是如果与以前众所周知的危险因素和 VAS 相结合。观点：在急性带状疱疹患者中，具有神经性疼痛特征的受试者表现出较高的 PHN 频率。 S-LANSS 等筛查神经性疼痛的工具可能有助于预测 PHN 并实现疼痛管理的早期干预。 (C) 2014 年，美国疼痛协会
Postherpetic neuralgia (PHN) is one of the most severe sequelae of herpes zoster events. Several risk factors have been reported for PHN, including old age, severe skin rash, and intense pain. This study therefore aims to evaluate the usefulness of the Self-completed Leeds Assessment of Neuropathic Symptoms and Signs pain scale (S-LANSS) in conjunction with previously reported risk factors for predicting PHN. A group of herpes zoster patients (N = 305) were included in the cohort study. Subjects were asked for their demographic information, clinical symptoms and signs, intensity of pain by visual analog scale (VAS), and S-LANSS. They were followed up in clinical visits or via telephone for 12 months. Nineteen patients (6.2%) suffered from PHN in this study. Using logistic regression, 3 risk factors for PHN were identified: age >= 70 years, high VAS scores, and high S-LANSS scores. Prediction of PHN using VAS (>= 8) and S-LANSS (>= 15) criteria achieved a sensitivity of 78.9% and specificity of 78.0%. Prediction of PHN in elderly patients (>= 70 years), using the criteria of VAS (>= 6) and S-LANSS (>= 15) as well, achieved 100% sensitivity and 57.1% specificity. S-LANSS could be a useful prediction tool for PHN, particularly if combined with previously well-known risk factors and VAS.Perspective: Among acute herpes zoster patients, subjects with characteristics of neuropathic pain showed high frequency of PHN. The tools for screening neuropathic pain like S-LANSS could be helpful for predicting PHN and enabling early intervention of pain management. (C) 2014 by the American Pain Society