Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.
Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.
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DOI：
10.4049/jimmunol.141.7.2200
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发表时间：
1988-10
影响因子：
4.4
通讯作者：
R. P. Bucy;C.-L. H. Chen;J. Cihak;U. Lösch;M D Cooper
中科院分区：
文献类型：
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作者：
R. P. Bucy;C.-L. H. Chen;J. Cihak;U. Lösch;M D Cooper
用一组针对鸡CD3、CD4、CD8、TCR-γ增量和TCR-αβ同源物的鼠单抗研究了表达这些标记的T细胞在鸡淋巴组织切片中的分布。这些研究表明，具有这两类TCR的T细胞占据了不同的组织微环境。TCR1+细胞(Gamma Delta TCR同源物)主要定位于脾血窦和肠上皮，其中大部分表达CD8同源物。TCR2+细胞(α-β-TCR同源物)主要分布于脾小动脉周围鞘和肠道固有层，其中大部分表达CD4同源物。胸腺中这两类T细胞的频率和分布也是独一无二的。TCR1和TCR2细胞的不同组织归巢模式表明，它们代表着不同的T细胞谱系，具有不同的生理作用。
A panel of murine mAb specific for the chicken homologues of the CD3, CD4, CD8, TCR gamma delta, and TCR alpha beta has been used to study the distribution of T cells expressing these markers in sections of chicken lymphoid tissues. These studies have revealed that the T cells possessing the two classes of TCR occupy distinct histologic microenvironments. The TCR1+ cells (gamma delta TCR homologue) are localized preferentially in the splenic sinusoids and the intestinal epithelium, where most of them express the CD8 homologue. The TCR2+ cells (alpha beta TCR homologue), a majority of which express the CD4 homologue, are found primarily in the splenic periarteriolar sheath and the lamina propria of the intestine. The frequency and distribution of the two classes of T cells in the thymus is also unique. The different tissue homing patterns of the TCR1 and TCR2 cells suggest that they represent separate lineages of T cells with distinctive physiologic roles.