Biomaterial structure in deep-sea bamboo coral (Anthozoa: Gorgonacea: Isididae):: perspectives for the development of bone implants and templates for tissue engineering
Biomaterial structure in deep-sea bamboo coral (Anthozoa: Gorgonacea: Isididae):: perspectives for the development of bone implants and templates for tissue engineering
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DOI：
10.1002/mawe.200600036
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发表时间：
2006-06-01
影响因子：
1.1
通讯作者：
Worch, H.
中科院分区：
文献类型：
--
作者：
Ehrlich, H.;Etnoyer, P.;Worch, H.
来自海洋的天然结构生物材料，包括软体动物贝壳、海绵和珊瑚，不仅提供了丰富的新型骨和软骨替代材料的来源，而且还激发了人们对开发纳米仿生复合材料的研究。本研究描述了深海竹珊瑚的超微结构，以及某些间隙表面的纳米结构与生物矿化现象。被检查的珊瑚的骨骼显示出大的骨钙质结构的连接轴与较小的促性腺激素蛋白结节交替，使生物的骨骼残骸呈现出数字化的外观，就像陆地竹子。为了验证竹珊瑚节间具有类骨的力学和生化性质的假设，对这些天然生物矿物复合材料进行了结构和生化分析，并分离出蛋白质组分。由于其在人类成骨细胞和破骨细胞中的高定植潜力，由酸性纤维蛋白骨架组成的有机基质被证明是一种非常成功的组织工程应用模型。钙质节间的材料属性与骨科手术中使用的材料的材料属性图具有很好的相关性，尽管这些材料比骨骼更致密和更坚固。本研究的结果也清楚地表明了柳珊瑚黄素的喹酮蛋白性质。基于所获得的结果具有很高的仿生潜力，将Isididae珊瑚用作“活骨植入物”及其生物技术水产养殖似乎在不久的将来很有希望。
Natural structural biomaterials of marine origin including mollusc shells, sponges and corals not only provide an abundant source of novel bone and cartilage replacements but also inspire investigations to develop nano-sized biomimetic composites. This study presents a characterisation of the ultrastructure of the deep-sea Bamboo coral (Anthozoa: Gorgonacea: Isididae) and the nanostructure of some interstitial surfaces with respect to biomineralization phenomena. The skeletons of the corals examined exhibit jointed axes of large bony calcareous structures alternated with smaller proteinaceous nodes of gorgonin, giving the skeletal remains of the organism a digitated appearance, like terrestrial bamboo. To test the hypothesis that bamboo coral internodes exhibit bone-like mechanical and biochemical properties, structural and biochemical analyses of these natural biomineral composites and separation of proteinaceous components was performed. Due to its high potential for colonization with both human osteoblasts and osteoclasts, the organic matrix, composed of an acidic fibrillar protein framework, proved to be a very successful model for possible applications in tissue engineering. The material properties of the calcareous internodes correlate well with the material property charts for materials used in orthopedic surgery, though denser and stronger than bone. Results of the present study also clearly indicate the quinonproteinaceous nature of the gorgonin. On the basis of the high biomimetic potential of the results obtained, the use of Isididae corals as "living bone implants" as well as their biotechnological aquacultural cultivation seems to be promising for the near future.