Melanin -instructed biomimetic synthesis of copper sulfide for cancer phototheranostics
Melanin -instructed biomimetic synthesis of copper sulfide for cancer phototheranostics
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黑色素指导仿生合成硫化铜用于癌症光治疗
DOI：
10.1016/j.cej.2020.124232
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发表时间：
2020
影响因子：
15.1
通讯作者：
Huang Peng
中科院分区：
文献类型：
--
作者：
Qi Chao;Jiang Chao;Fu Lian-Hua;Sun Tuanwei;Wang Tianfu;Lin Jing;Nie Zhihong;Huang Peng
仿生合成是制备具有良好生物相容性的纳米治疗药物的一种很有前途的方法。在此，我们报告了一种仿生的方法来合成叶酸（FA）修饰的硫化铜（CuS）纳米点的癌症光疗诊断，通过使用黑色素作为生物模板和FA作为稳定剂。由于黑色素对金属离子的高亲和力，铜离子可以吸附在黑色素表面，然后与S2−离子反应形成CuS纳米点。黑色素作为一种天然生物分子，具有良好的生物相容性和生物降解性，可有效提高所制备的硫化铜纳米点的生物安全性。更重要的是，黑色素和CuS都具有很强的近红外（NIR）吸收，所制备的具有高光热转换效率的CuS-Melanin-FA复合纳米探针有望用于增强光声成像和癌症的光热治疗，这在4 T1荷瘤小鼠上得到了证实。此外，仿生合成方法制备硫化铜纳米点开辟了一个新的视野，仿生合成的其他纳米治疗。
Biomimetic synthesis is a promising strategy for the preparation of nanotheranostics with excellent biocompatibility. Herein, we report a biomimetic approach to synthesize folic acid (FA) modified copper sulfide (CuS) nanodots for cancer phototheranostics by using melanin as a biotemplate and FA as a stabilizer. Owing to the high affinity of melanin for metal ions, copper ions can be adsorbed on the surface of melanin and then reacted with S2−ions to form CuS nanodots. As a natural biomolecule, melanin has high biocompatibility and biodegradability, which can effectively improve the biosafety of the prepared CuS nanodots. More importantly, both melanin and CuS have strong near-infrared (NIR) absorption, the as-prepared CuS-Melanin-FA composite nanoprobes with high photothermal conversion efficiency are promising for augmented photoacoustic imaging and photothermal therapy of cancer, which is demonstrated on 4T1 tumor-bearing mice. Moreover, the biomimetic synthesis method for the preparation of CuS nanodots opens a new horizon for the biomimetic synthesis of other nanotheranostics.