Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.
Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.
复制标题
减毒活疫苗和全灭活猿猴免疫缺陷病毒疫苗对抗强毒 SIV 阴道攻击的功效。
DOI：
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发表时间：
1992
影响因子：
0.7
通讯作者：
Niels Pedersen
中科院分区：
文献类型：
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作者：
M. Marthas;Christopher J. Miller;S. Sutjipto;Joanne Higgins;Judy Torten;B. Lohman;Ronald E. Unger;Ross A. Ramos;Hiroshi Kiyono;Jerry R. McGhee;P. Marx;Niels Pedersen
研究了两种疫苗制剂（肌肉注射补骨脂素灭活SIV和阴道注射减毒SIV）在恒河猴中预防强毒性SIV生殖器传播的能力。接种SIV全灭活疫苗的6只猕猴中有2只，接种SIV减毒活疫苗的5只猕猴中有3只，以及6只对照中的4只在两次单独的阴道内接种50%动物感染剂量的SIV后持续感染。未观察到攻毒前血清或阴道分泌物中SIV特异性抗体水平与随后感染强毒性SIV之间的关联。
The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.
病毒剂量和nonoxynol-9对SIV在恒河猴中生殖器传播的影响。
影响因子：
0.7
作者：
Miller,CJ;Alexander,NJ;Sutjipto,S;Joye,SM;Hendrickx,AG;Jennings,M;Marx,PA
通讯作者：
Marx,PA
恒河猴免受猿猴免疫缺陷病毒感染的疫苗保护。
影响因子：
1.5
作者：
Carlson,JR;McGraw,TP;Keddie,E;Yee,JL;Rosenthal,A;Langlois,AJ;Dickover,R;Donovan,R;Luciw,PA;Jennings,MB
通讯作者：
Jennings,MB
针对 SIV 感染和疾病的疫苗接种。
影响因子：
1.5
作者：
Gardner,MB
通讯作者：
Gardner,MB