Sporulation: how to survive on planet Earth (and beyond).
Sporulation: how to survive on planet Earth (and beyond).
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DOI：
10.1007/s00294-017-0694-7
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发表时间：
2017-10
期刊：
影响因子：
2.5
通讯作者：
Hull CM
中科院分区：
文献类型：
--
作者：
Huang M;Hull CM
孢子形成是一种策略，多种生物可以适应其各个环境壁ni的变化，并在时间和/或空间中生存，直到它们遇到可接受的营养生长的条件为止。细菌产生的孢子一直是广泛研究的主题，枯草芽孢杆菌等几种系统为了解孢子生物发生和发芽的分子基础提供了足够的机会。相比之下，其他微生物（例如真菌）的孢子相对较少了解。在模型系统中进行孢子形成的研究，例如酿酒酵母和曲霉菌的研究，已经建立了研究真核孢子的基础，但是在分子水平上，关于孢子的功能知之甚少。在人类真菌病原体的孢子中，尤其如此，例如致命真菌疾病的最常见原因，即新虫。最近的蛋白质组学研究有助于确定形成，持久并发芽的致病真菌孢子的分子机制，以积极生长的人类疾病剂。
Sporulation is a strategy widely utilized by a wide variety of organisms to adapt to changes in their individual environmental niches and survive in time and/or space until they encounter conditions acceptable for vegetative growth. The spores produced by bacteria have been the subjects of extensive studies, and several systems such as Bacillus subtilis have provided ample opportunities to understand the molecular basis of spore biogenesis and germination. In contrast, the spores of other microbes, such as fungi, are relatively poorly understood. Studies of sporulation in model systems such as Saccharomyces cerevisiae and Aspergillus nidulans have established a basis for investigating eukaryotic spores, but very little is known at the molecular level about how spores function. This is especially true among the spores of human fungal pathogens such as the most common cause of fatal fungal disease, Cryptococcus neoformans. Recent proteomic studies are helping to determine the molecular mechanisms by which pathogenic fungal spores are formed, persist, and germinate into actively growing agents of human disease.