The polymorphism -1131T>C in apolipoprotein A5 gene is associated with dyslipidemia in Brazilian subjects
The polymorphism -1131T>C in apolipoprotein A5 gene is associated with dyslipidemia in Brazilian subjects
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DOI：
10.1016/j.gene.2012.12.016
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发表时间：
2013-03-01
期刊：
影响因子：
3.5
通讯作者：
Sousa, Marinez O.
中科院分区：
文献类型：
--
作者：
Ferreira, Claudia N.;Carvalho, Maria G.;Sousa, Marinez O.
背景：在许多人群中，载脂蛋白A5基因(APOA5)的多态性与较高的甘油三酯水平相关。本研究的目的是确定APOA5-1131T和GT；C基因多态性的等位基因和基因型分布，并确定该基因变异与血脂异常风险的关系。方法：对109名血脂异常患者和107名对照进行基因分型。酶法测定总胆固醇、甘油三酯和高密度脂蛋白胆固醇。组间均数比较采用方差分析。结果：等位基因C在血脂异常人群中的分布频率明显高于对照组(p=0.019)，并增加了个体患血脂异常的风险(OR=1.726，CI 95%=1.095~2.721)。按性别进行的基因分型分析显示，该等位基因在血脂异常男性中的频率较高(P=0.037；OR=2.050，CI 95%=1.042-4.023)。按基因TT和TC/CC分析，C基因携带者的胆固醇和甘油三酯水平高于TT纯合子(p分别为0.046和0.049)。结论：等位基因C在血脂异常的成人中具有较高的总胆固醇和甘油三酯水平。APOA5-1131T>；C基因多态性与男性血脂异常相关。(C)2012爱思唯尔B.V.保留所有权利。
Background: Polymorphisms in apolipoprotein A5 gene (APOA5) have been associated with higher triglyceride levels in many populations. The aim of the study was to determine the allelic and genotypic distribution of the APOA5 - 1131T>C polymorphism and to identify the association of the genetic variant and the risk for dyslipidemia.Methods: We genotyped 109 dyslipidemic subjects and 107 controls. The total cholesterol, triglycerides and HDL-c were determined enzymatically. Comparison of means among groups was calculated by ANOVA. Significant differences among groups were evaluated by Student-Newman-Keuls test.Results: The minor allele C was more frequent in dyslipidemic subjects than controls (p = 0.019) and confers an increased individual risk for dyslipidemia (OR = 1.726, Cl 95% = 1.095-2.721). The genotype analysis by gender showed that this allele was more frequent in dyslipidemic males (p = 0.037; OR = 2.050, CI 95%= 1.042-4.023). When participants were analyzed according to genotypes TT and TC/CC, C-carriers presented higher cholesterol and triglycerides levels than TT homozygous (p = 0.046 and 0.049, respectively).Conclusions: The allele C confers higher total cholesterol and triglycerides levels in dyslipidemic adults. The APOA5 - 1131T>C polymorphism is associated with dyslipidemia in male subjects. (C) 2012 Elsevier B.V. All rights reserved.