Organic Photo-antimicrobials: Principles, Molecule Design, and Applications
Organic Photo-antimicrobials: Principles, Molecule Design, and Applications
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DOI：
10.1021/jacs.1c08679
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发表时间：
2021-10-22
影响因子：
15
通讯作者：
Peng, Xiaojun
中科院分区：
文献类型：
--
作者：
Ran, Bei;Wang, Zuokai;Peng, Xiaojun
多重耐药病原体的出现威胁着全球的医疗保健系统。光抗微生物剂（PAM）介导的光疗（PT）方法的最新进展为当前严重的抗生素耐药性提供了新的机会。在PT治疗过程中，PAM产生的活性氧或热量会与细胞膜反应，从而泄漏细胞质成分，并有效地消灭不同的病原体，如细菌，真菌，病毒，甚至寄生虫。该观点将集中于不同有机光抗菌剂（OPAM）的开发及其作为实用治疗剂在局部感染治疗，伤口敷料和医疗器械生物膜去除中的应用。我们还讨论了如何通过改变化学结构或与靶向组分缀合来设计高效的OPAM。此外，本《展望》还讨论了《行动政策》面临的一般挑战和方向，以及需要进一步开展的工作。希望通过这一概述，OPAM能够蓬勃发展，并在未来更广泛地用于微生物感染，特别是在全球COVID-19疫情日益严重的时候。
The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for the current serious antibiotic resistance. During the PT treatment, reactive oxygen species or heat produced by PAMs would react with the cell membrane, consequently leaking cytoplasm components and effectively eradicating different pathogens like bacteria, fungi, viruses, and even parasites. This Perspective will concentrate on the development of different organic photo-antimicrobials (OPAMs) and their application as practical therapeutic agents into therapy for local infections, wound dressings, and removal of biofilms from medical devices. We also discuss how to design highly efficient OPAMs by modifying the chemical structure or conjugating with a targeting component. Moreover, this Perspective provides a discussion of the general challenges and direction for OPAMs and what further needs to be done. It is hoped that through this overview, OPAMs can prosper and will be more widely used for microbial infections in the future, especially at a time when the global COVID-19 epidemic is getting more serious.