Primary thyroid lymphoma: The 40 year experience of a UK lymphoma treatment centre
Primary thyroid lymphoma: The 40 year experience of a UK lymphoma treatment centre
复制标题
DOI：
10.3892/ijo.2012.1387
复制
发表时间：
2012-06-01
影响因子：
5.2
通讯作者：
Hancock, B. W.
中科院分区：
文献类型：
--
作者：
Alzouebi, M.;Goepel, J. R.;Hancock, B. W.
我们报告40年未选择的经验，英国淋巴瘤治疗中心。1970年至2010年间，谢菲尔德淋巴瘤小组治疗了3363例非霍奇金淋巴瘤。在此期间发现了70例原发性甲状腺淋巴瘤。本回顾性审查的临床和病理特征的患者甲状腺淋巴瘤包括在英国进行的最大的系列之一。该系列包括57名女性和13名男性，诊断时的中位年龄为69.5岁。病理亚型为弥漫性大b细胞淋巴瘤（DLBCL） 50例，MALT淋巴瘤13例，无性b细胞淋巴瘤（NOS） 6例，T细胞淋巴瘤1例。在64例完全分期的患者中，53例为IE期，11例为IIE期。治疗方式包括手术、化疗、放疗或联合治疗。DLBCL、MALT淋巴瘤和惰性b细胞淋巴瘤NOS的5年生存率分别为45%、62%和75%，所有组织学亚型的中位总生存期为68个月（范围0-148）或5.7年。这个系列的结果证实了以前的经验。如果手术后需要治疗，单纯放疗就足以治疗I期和II期低级别甲状腺淋巴瘤。对于高级别甲状腺淋巴瘤，联合化疗或适当化疗后放疗是必要的。
We report the 40-year unselected experience of a UK lymphoma treatment centre. Between 1970 and 2010, 3363 cases of non-Hodgkin lymphoma were managed by the Sheffield Lymphoma Team. Seventy cases of primary thyroid lymphoma were identified during this time. This retrospective review of the clinical and pathological features of patients with thyroid lymphoma comprises one of the largest series conducted in the UK. The series included 57 females and 13 males with a median age at diagnosis of 69.5. The pathological subtypes were diffuse large B-cell lymphoma (DLBCL) in 50 patients, MALT lymphoma in 13, indolent B-cell lymphoma not otherwise specified (NOS) in 6 and T cell lymphoma in one patient. Of the 64 patients fully staged, 53 had Stage IE and 11 Stage IIE disease. Management modalities included surgery, chemotherapy, radiotherapy or combination treatment. Five-year survival rates for DLBCL, MALT lymphoma and indolent B-cell lymphoma NOS were 45%, 62% and 75%, respectively, with a median overall survival of all histological subtypes of 68 months (range 0-148) or 5.7 years. The outcomes of this series confirm previous experience. If treatment is needed after surgery radiotherapy alone is sufficient for Stage I and II low grade thyroid lymphoma. Combination chemotherapy or adequate chemotherapy followed by radiotherapy is warranted in high grade thyroid lymphoma.