Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
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DOI：
10.1021/nl061412u
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发表时间：
2006-11-08
期刊：
影响因子：
10.8
通讯作者：
Gao, Jinming
中科院分区：
文献类型：
--
作者：
Nasongkla, Norased;Bey, Erik;Gao, Jinming
我们描述了多功能聚合物胶束的发展，通过α（V）β（3）整合素，控制药物输送，和有效的磁共振成像（MRI）的对比度特性的癌症靶向能力。阿霉素和一簇超顺磁性氧化铁（SPIO）纳米粒子成功地装载在胶束核心。胶束表面上cRGD的存在导致癌症靶向递送至表达α（v）β（3）的肿瘤细胞。体外MRI和细胞毒性研究证明了这些多功能聚合物胶束的超灵敏MRI成像和α（v）β（3）特异性细胞毒性反应。
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide ( SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.