A comparative study of eight cell lines derived from human testicular teratocarcinoma
A comparative study of eight cell lines derived from human testicular teratocarcinoma
复制标题
八种人睾丸畸胎瘤细胞系的比较研究
DOI：
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发表时间：
1980
影响因子：
6.4
通讯作者：
B. Knowles
中科院分区：
文献类型：
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作者：
P. Andrews;P. Andrews;D. Bronson;F. Benham;S. Strickland;B. Knowles
从人睾丸生殖细胞肿瘤中提取的8个独立细胞系，检测了各种标记物的表达。这些包括主要的组织相容性和胚胎抗原、绒毛膜促性腺激素、甲胎蛋白、碱性磷酸酶、纤溶酶原激活剂和SV40的感染性。没有细胞系主要由绒毛膜癌或卵黄囊细胞组成，但有几个细胞系含有类似小鼠胚胎癌的细胞；当注射到免疫抑制的动物体内时，其中一些细胞系形成了具有胚胎癌特征的肿瘤。有人提出，与小鼠不同，人类胚胎癌细胞对应于前囊胚发育阶段。
Eight independent cell lines, derived from human testicular germ‐cell tumors, were examined for the expression of various markers. These included major histocompatibility and embryonic antigens, chorionic gonadotropin, alpha fetoprotein, alkaline phosphatase, plasminogen activator, and infectivity by SV40. No line consisted primarily of choriocarcinoma or yolk sac cells, but several contained cells resembling murine embryonal carcinoma; some of these lines formed tumors with the distinctive features of embryonal carcinoma when injected into immunosuppressed animals. It is proposed that human embryonal carcinoma cells, unlike those of the mouse, correspond to a preblastocyst stage of development.