Retrospective evaluation of histopathological examinations in invasive ductal breast cancer of no special type: an analysis of 691 patients
Retrospective evaluation of histopathological examinations in invasive ductal breast cancer of no special type: an analysis of 691 patients
复制标题
DOI：
10.5114/aoms.2015.53964
复制
发表时间：
2017-01-01
影响因子：
3.8
通讯作者：
Patera, Janusz
中科院分区：
文献类型：
--
作者：
Badowska-Kozakiewicz, Anna M.;Liszcz, Anna;Patera, Janusz
导言：浸润性导管癌(IDC)是女性最常见的乳腺癌类型，约占乳腺癌总数的80%。材料和方法：691例IDC-NST患者的组织学标本。结果：在我们自己的研究资料中，非特殊类型的浸润性导管癌占60%以上，其中G2(53.96%)和G3型(28.98%)所占比例最大。就肿瘤大小而言，IDC-NST最常见的肿瘤是T1c期(34.59%)和T2期(35.31%)。45.44%的IDC-NST肿瘤无淋巴结转移。在组织病理学分析中，淋巴结转移与组织学恶性程度(N0/G1-G3p=0.0103；N1a/G1-G3p=0.0498；N1b/G1-G3p<；0.001；N3/G1-G3p=0.0027；N4/G1-G3p<；0.001)、淋巴结转移与肿瘤大小(N0/T1-T4p=0.00295；N1b/T1-T4p<；0.001；N2/T1-T4p<；0.001)显著相关。0.001；N2a/T1-T2p<；0.001；N4/T1-T4p<；0.001；Nx/t1-T4p=0.0447)，以及组织学恶性程度与肿瘤大小的关系(G1/T1-T4p<；0.001；G1/2/T1-T4p<；0.001；G2/3/T1-T4p<；0.0267)。结论：乳腺癌最常见的组织学类型为非特殊类型浸润性导管癌(IDC-NST)；在IDC-NST患者中，淋巴结受累情况与组织学恶性程度或肿瘤大小以及组织学恶性程度与肿瘤大小之间均有统计学意义的相关性。
Introduction: Invasive ductal carcinoma (IDC) is the most common type of breast cancer in women and accounts for about 80% of all breast cancers.Material and methods: The material consisted of histological preparations derived from 691 patients treated for IDC-NST.Results: In our own study material, invasive ductal breast cancer of no special type accounted for more than 60% of cases, with the largest percentage of tumors being classified as G2 (53.96%) and G3 (28.98%). In terms of tumor size, the most common IDC-NST tumors were those of stage T1c (34.59%) and T2 (35.31%). The incidence of lymph node involvement was also assessed to reveal that no lymph node metastases were present in 45.44% of IDC-NST tumors. In the histopathological analysis of IDC-NST, significant statistical correlation was demonstrated between the presence of lymph node metastases and the histological malignancy grade (N0/G1-G3 p = 0.0103; N1A/G1-G3 p = 0.0498; N1B/G1-G3 p< 0.001; N3/G1-G3 p = 0.0027; N4/G1-G3 p < 0.001), between the presence of lymph node metastases and the tumor size (N0/T1-T4 p = 0.00295; N1B/T1-T4 p < 0.001; N2/T1-T4 p < 0.001; N2A/T1-T2 p < 0.001; N4/T1-T4 p < 0.001; Nx/T1-T4 p = 0.0447), as well as between the histological malignancy grade and the tumor size (G1/T1-T4 p < 0.001; G1/2/T1-T4 p < 0.001; G2/3/T1-T4 p < 0.0267).Conclusions: Own research demonstrated that the most common histological type of breast cancer is invasive ductal carcinoma of no special type (IDC-NST); statistically significant correlations were demonstrated in IDC-NST patients between the lymph node involvement status and the histological malignancy grade or tumor size as well as between the histological malignancy grade and the tumor size.