Breast-density measurement using photon-counting spectral mammography.
Breast-density measurement using photon-counting spectral mammography.
复制标题
使用光子计数光谱乳房X线照相术进行乳房密度测量。
DOI：
10.1002/mp.12279
复制
发表时间：
2017
期刊：
影响因子：
3.8
通讯作者：
Fredenberg,Erik
中科院分区：
文献类型：
--
作者：
Johansson,Henrik;vonTiedemann,Miriam;Erhard,Klaus;Heese,Harald;Ding,Huanjun;Molloi,Sabee;Fredenberg,Erik
目的评价光子计数能谱乳腺摄影测量乳腺密度的方法。乳腺密度是乳腺癌风险和乳腺X线摄影诊断准确性的一个指标，可作为个性化筛查、治疗监测和剂量估计的输入。MethodsThe测量方法采用脂肪和乳腺组织之间X射线衰减的谱差，不依赖于任何先验信息。使用组织等效材料（平板和乳房形体模）上的体模测量值和筛选人群的临床数据对该方法进行了评价（）。一个国家的最先进的nonspectral乳腺密度评估方法被用于benchmarking.ResultsThe的频谱方法的精度估计为1.5-1.8个百分点（PP）乳腺密度。在筛选人群中观察到厚度与乳腺密度、致密体积、乳腺体积和压迫高度的预期相关性。密度范围为4.5%-99.6%，呈偏态分布，众数为12.5%，中位数为18.3%，平均值为23.7%。非光谱方法的精密度估计为2.7-2.8 pp。主要的不确定性的nonspectral方法起源于厚度估计，特别是薄/致密的乳房造成的问题相比，spectral method.ConclusionsThe光谱方法产生了合理的结果，在筛查人群的精度约为2倍的nonspectral方法，这可能会提高或使应用程序的乳腺密度测量在个体的基础上，如治疗监测和个性化筛选。
PurposeTo evaluate a method for measuring breast density using photon‐counting spectral mammography. Breast density is an indicator of breast cancer risk and diagnostic accuracy in mammography, and can be used as input to personalized screening, treatment monitoring and dose estimation.MethodsThe measurement method employs the spectral difference in x‐ray attenuation between adipose and fibro‐glandular tissue, and does not rely on any a priori information. The method was evaluated using phantom measurements on tissue‐equivalent material (slabs and breast‐shaped phantoms) and using clinical data from a screening population (). A state‐of‐the‐art nonspectral method for breast‐density assessment was used for benchmarking.ResultsThe precision of the spectral method was estimated to be 1.5–1.8 percentage points (pp) breast density. Expected correlations were observed in the screening population for thickness versus breast density, dense volume, breast volume, and compression height. Densities ranged between 4.5% and 99.6%, and exhibited a skewed distribution with a mode of 12.5%, a median of 18.3%, and a mean of 23.7%. The precision of the nonspectral method was estimated to be 2.7–2.8 pp. The major uncertainty of the nonspectral method originated from the thickness estimate, and in particular thin/dense breasts posed problems compared to the spectral method.ConclusionsThe spectral method yielded reasonable results in a screening population with a precision approximately two times that of the nonspectral method, which may improve or enable applications of breast‐density measurement on an individual basis such as treatment monitoring and personalized screening.