Hoxc13 mutant mice lack external hair
Hoxc13 mutant mice lack external hair
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DOI：
10.1101/gad.12.1.11
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发表时间：
1998-01-01
影响因子：
10.5
通讯作者：
Capecchi, MR
中科院分区：
文献类型：
--
作者：
Godwin, AR;Capecchi, MR
Hox 基因通常在时间和空间上以共线方式表达，相对于它们在 Hox 复合体中的位置。与旁系同源组 13 成员的预期模式一致，在指甲和尾巴中发现了早期胚胎 Hoxc13 表达。 Hoxc13 也在触毛、舌头的丝状乳头和全身的毛囊中表达；显然违反空间共线性的模式。携带 Hoxc13 突变等位基因的小鼠是通过基因靶向产生的。纯合子在基因表达的每个区域都有缺陷。最显着的缺陷是毛发脆弱，导致脱发（无毛小鼠）。对于这一新作用的一种解释是，Hoxc13 已被招募用于头发、指甲和丝状乳头发育的常见功能。
Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibrissae, in the filiform papillae of the tongue, and in hair follicles throughout the body; a pattern that apparently violates spatial colinearity. Mice carrying mutant alleles of Hoxc13 have been generated by gene targeting. Homozygotes have defects in every region in which gene expression is seen. The most striking defect is brittle hair resulting in alopecia (hairless mice). One explanation for this novel role is that Hoxc13 has been recruited for a function common to hair, nail, and filiform papilla development.