Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
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DOI：
10.1006/nlme.1998.3858
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发表时间：
1999-01-01
影响因子：
2.7
通讯作者：
Maldonado, H
中科院分区：
文献类型：
--
作者：
Hermitte, G;Pedreira, ME;Maldonado, H
一个不透明的屏幕在头顶上移动eldibs的逃避反应，在几个演示后习惯了很长一段时间（长期习惯化，LTH）。先前的研究结果表明，间隔（15次试验间隔171秒）和集中训练（300次试验无休息间隔）与LTH的两种不同记忆成分相关。本实验旨在进一步研究这些成分的作用机制。结果表明，LTH。通过间隔训练而不是集中训练获得的LTH被训练-测试环境转换或训练前或训练后注射放线菌酮（15-25 μ g）阻断，间隔训练后的LTH持续时间（5天）长于集中训练后（2天）。基于这些结果提出了一个区分两个LTH记忆成分的模型：（上下文信号）LTH由间隔训练产生，依赖于上下文，对环己酰亚胺（CYX）敏感，并且持久;和（信号）LTH由大规模训练产生，仅依赖于信号不变性，对CYX不敏感，并且持续时间较短。(C)北京：科学出版社.
An opaque screen moving overhead elicits an escape response in the crab Chasmagnathus that after a few presentations habituates for a long period (long-term habituation, LTH). Previous results suggested that spaced (15 trials separated by 171 s) and massed training (300 trials without rest interval) were correlated with two different memory components of LTH. The present experiments were aimed at further studying the mechanisms subserving these components. Results indicate that LTH. acquired by spaced but not by massed training is blocked either by a training-to-testing context shift or by cycloheximide (15-25 mu g) pre- or posttraining injection and that LTH after spaced training persists for longer time (5 days) than after massed training (2 days). A model based on these results that distinguishes two LTH-memory components is proposed: a (context-signal) LTH yielded by spaced training, dependent of context, sensitive to cycloheximide (CYX), and long lasting; and a (signal) LTH yielded by massed training, dependent only on the signal invariance, insensitive to CYX, and Shorter lasting. (C) 1999 Academic Press.