The impact of circulating total homocysteine levels on long-term cardiovascular mortality in patients with acute coronary syndromes
The impact of circulating total homocysteine levels on long-term cardiovascular mortality in patients with acute coronary syndromes
复制标题
DOI：
10.1016/j.ijcard.2007.02.011
复制
发表时间：
2008-03-14
影响因子：
3.5
通讯作者：
Argyrakis, Spyros K.
中科院分区：
文献类型：
--
作者：
Foussas, Stefanos G.;Zairis, Michael N.;Argyrakis, Spyros K.
工作背景：在ST段抬高型心肌梗死（STEMI）或非ST段抬高型急性冠脉综合征患者中，评价循环总同型半胱氨酸（tHcy）水平对长期心血管死亡率的可能独立影响方法：共458名STEMI和476名NSTE-ACS患者，他们分别在指数疼痛的前12小时和24小时内连续出现。根据呈现时的循环tHcy水平的三分位数将每个群组划分。早期（30天）和晚期结果：ST段抬高型心肌梗死（STEMI）患者tHcy三分位数之间30天心血管死亡风险无差异（第一、第二和第三个三分位数分别为7.2%、8.5%和12.4%; P趋势=0.3）或NSTE-ACS（第一、第二和第三个三分位数分别为3.1%、3.8%和5.7%; P趋势=0.5）。在STEMI患者中，tHcy水平较高三分位数的患者晚期（从31天到5年）心血管死亡的未校正风险显著高于其他两个三分位数的患者（第一、第二和第三个三分位数分别为23.4%、27.9%和41.8%; P趋势
Background: To evaluate the possible independent impact of circulating total homocysteine (tHcy) levels on long-term cardiovascular mortality, in patients with either ST-segment elevation myocardial infarction (STEMI), or non-ST-segment elevation acute coronary syndromes (NSTE-ACS).Methods: A total of 458 STEMI and 476 NSTE-ACS patients who presented consecutively, within the first 12 and 24 h of index pain respectively were studied. Each cohort was divided according to tertiles of circulating tHcy levels upon presentation. Early (30 days) and late (31 days through 5 years) cardiovascular mortality was the predefined study endpoint.Results: There was no difference in the risk of 30-day cardiovascular death among the tertiles of tHcy in patients with STEMI (7.2%, 8.5% and 12.4% for the first, second and third tertiles respectively; P-trend=0.3) or NSTE-ACS (3.1%, 3.8% and 5.7% for the first, second and third tertiles respectively; P-trend=0.5). Patients in the upper tHcy tertile were at significantly higher unadjusted risk of late (from 31 days trough 5 years) cardiovascular death than those in the other two tertiles in STEMI (23.4%, 27.9% and 41.8% for the first, second and third tertiles respectively; P-trend