Enlarging the "Audacious Goal": Elimination of the world's high prevalence neglected tropical diseases
Enlarging the "Audacious Goal": Elimination of the world's high prevalence neglected tropical diseases
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DOI：
10.1016/j.vaccine.2011.06.024
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发表时间：
2011-12-30
期刊：
影响因子：
5.5
通讯作者：
Hotez, Peter
中科院分区：
文献类型：
--
作者：
Hotez, Peter
被忽视的热带病（NTD）的高流行率显示了全球疾病负担，超过了疟疾，结核病和其他众所周知的全球健康状况：它们也是使世界上最贫穷的人陷入贫困的强大力量。通过针对七种最常见的NTD的极低成本的疾病绘图和大规模药物管理（MDA）国家方案，在美国国际开发署（USAID）、英国国际开发部（DFID）和NTD全球网络及其合作伙伴的支持下，超过14个国家现已开展NTD综合控制和消除工作。据世界卫生组织（WHO）估计，2008年，75个国家约有6.7亿人通过这些和其他赞助项目接受了NTD治疗。随着持续的成功，下一个十年可能会见证全球消除致盲性沙眼、非洲人类锥虫病（HAT）、淋巴丝虫病（LF）、盘尾丝虫病、沙眼和麻风病等公共卫生问题，以及根除麦地那龙线虫病。对于其他高患病率NTD，包括钩虫感染、血吸虫病。查加斯病和利什曼病，可能仍然需要新的药物和疫苗。越来越多的人认识到，高患病率NTD表现出广泛的地理重叠和多寄生现象是普遍存在于世界各地的低收入国家。因此，全球消除还需要一揽子综合药物以及疫苗相关化疗。最终，全球消除高患病率NTD将需要美国政府和选定的欧洲政府的持续大规模支持，然而，新兴市场经济体（如巴西、中国、印度、墨西哥和尼日利亚）以及中东富裕国家也必须做出重大贡献。(C)2011爱思唯尔有限公司保留所有权利。
The high prevalence neglected tropical diseases (NTDs) exhibit a global disease burden that exceeds malaria, tuberculosis, and other better known global health conditions: they also represent a potent force in trapping the world's poorest people in poverty. Through extremely low cost national programs of disease mapping and mass drug administration (MDA) for the seven most common NTDs, integrated NTD control and elimination efforts are now in place in more than 14 countries through the support of the United States Agency for International Development (USAID), the British Department for International Development (DFID), and the Global Network for NTDs and its partners. The World Health Organization (WHO) estimates that in 2008 some 670 million people in 75 countries received NTD treatments through these and other sponsored programs. With continued successes the next decade could witness the global elimination of blinding trachoma, human Africa trypanosomiasis (HAT), lymphatic filariasis (LF), onchocerciasis, trachoma, and leprosy as public health problems, in addition to the eradication of dracunculiasis. For other high prevalence NTDs, including hookworm infection, schistosomiasis. Chagas disease and leishmaniasis, new drugs and vaccines may still be required. Increasingly it is recognized that the high prevalence NTDs exhibit extensive geographic overlap and polyparasitism is commonly found throughout the world's low income countries. Therefore, global elimination will also require integrated packages of drugs together with vaccine-linked chemotherapy. Ultimately, the global elimination of the high prevalence NTDs will require continued large-scale support from the U.S. Government and selected European governments, however, the emerging market economies, such as Brazil, China, India, Mexico, and Nigeria, and wealthy countries in the Middle East will also have to substantially contribute. (C) 2011 Elsevier Ltd. All rights reserved.