Right-hemispheric dominance of spatial memory in split-brain mice
Right-hemispheric dominance of spatial memory in split-brain mice
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DOI：
10.1002/hipo.20886
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发表时间：
2012-02-01
期刊：
影响因子：
3.5
通讯作者：
Shigemoto, Ryuichi
中科院分区：
文献类型：
--
作者：
Shinohara, Yoshiaki;Hosoya, Aki;Shigemoto, Ryuichi
人类大脑功能的左右不对称性已经被发现了世纪，尽管大脑侧化的许多分子和细胞基础仍然是难以捉摸的。最近的研究表明，海马CA 3-CA 1兴奋性突触是不对称排列的，然而，不对称回路的功能含义尚未在行为水平上进行研究。为了解决行为小鼠海马功能的左右不对称性，我们分析了裂脑小鼠在巴恩斯迷宫中的表现。裂脑小鼠接受腹侧海马连合和胼胝体横断，除了剥夺视觉输入从一只眼睛。在这样的小鼠中，视觉剥夺侧的海马体接收感觉驱动的输入。被迫使用右侧海马体的小鼠比被迫使用左侧海马体的小鼠取得了更好的空间任务表现。在二选择空间迷宫中，强迫使用左侧海马导致与右侧海马相当的表现，这表明两个海马半球都能够进行空间学习。因此，从巴恩斯迷宫获得的结果表明，使用右侧海马体提高了空间记忆的准确性。非空间的表现，但依赖于校园的任务（如恐惧条件反射）不受侧海马。(C)2010 Wiley Periodicals，Inc.
Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of split-brain mice in the Barnes maze. The split-brain mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus. (C) 2010 Wiley Periodicals, Inc.