Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis
Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis
复制标题
DOI：
10.1016/s0165-3806(03)00166-4
复制
发表时间：
2003-09-10
期刊：
影响因子：
--
通讯作者：
Verdi, JM
中科院分区：
文献类型：
--
作者：
Kendall, SE;Ryczko, MC;Verdi, JM
p75神经营养因子受体（p75(NTR)）是肿瘤坏死因子受体超家族的一员。p75（NTR）信号事件涉及细胞周期阻滞和细胞凋亡，这取决于配体结合后哪些效应分子与其胞内结构域相关。两种这样的效应蛋白，p75（NTR）相关的细胞死亡执行因子（NADE）和神经营养因子受体相互作用因子（NRIF）促进p75（NTR）介导的细胞凋亡，而雪旺细胞因子-1 （SC-1）介导神经营养因子依赖性退出细胞周期。了解这三种相互作用蛋白和p75 NI R在胚胎发生过程中的表达谱对于确定这些效应蛋白是否可能在p75（NTR）介导的信号事件之外发挥作用至关重要。NADE、NRIF和SC-1 mrna在小鼠发育过程中的分布表明，这些基因的作用实际上并不局限于p75（NTR）的表达区域。具体来说，在大脑发育过程中，NADE、NRIF和SC-1的空间和时间表达域的详细比较揭示了与p75（NTR）共表达的区域，但也说明了空间和时间表达的不同和不一致。这些结果对三种p75（NTR）相互作用蛋白的独特发育特征产生了新的见解，从而揭示了它们在胚胎发育过程中的多种信号传导潜力。(C) 2003 Elsevier B.V.版权所有
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily. p75(NTR) signaling events have been implicated in both cell cycle arrest and apoptosis depending on which effector molecules are associated with its intracellular domain after ligand binding. Two such effector proteins, p75(NTR)-associated cell death executor (NADE) and neurotrophin receptor interacting factor (NRIF) promote p75(NTR)-mediated apoptosis, whereas Schwann cell factor-1 (SC-1) mediates neurotrophin-dependent withdrawal from the cell cycle. An understanding of the expression profiles of these three interacting proteins and p75 NI R during embryogenesis is critical for addressing whether these effector proteins might function outside of p75(NTR)-mediated signaling events. The distribution of NADE, NRIF and SC-1 mRNAs during murine development suggests that the action of these genes is in fact not limited to regions of p75(NTR) expression. Specifically, a detailed comparison of the spatial and temporal expression domains of NADE, NRIF and SC-1 during brain development revealed regions of co-expression with p75(NTR) but also illustrates a distinct and discordant spatial and temporal expression. These results yield novel insights into the unique developmental characteristics of the three p75(NTR)-interacting proteins, thus revealing their diverse signaling potential during embryonic development. (C) 2003 Elsevier B.V. All rights reserved.