Limbic system perfusion in Alzheimer's disease measured by MRI-coregistered HMPAO SPET
Limbic system perfusion in Alzheimer's disease measured by MRI-coregistered HMPAO SPET
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DOI：
10.1007/s00259-002-0816-3
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发表时间：
2002-07-01
影响因子：
9.1
通讯作者：
Caldwell, CB
中科院分区：
文献类型：
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作者：
Callen, DJA;Black, SE;Caldwell, CB
本研究的目的是使用与磁共振 (MR) 图像对齐的配准单光子发射断层扫描 (SPET) 图像，对阿尔茨海默病 (AD) 患者的边缘灌注进行系统的半定量分析。将 40 名轻度至中度 AD 患者的边缘系统灌注与 17 名年龄、性别和教育程度匹配的正常对照 (NC) 进行比较。为每个受试者采集 HMPAO SPET 扫描和 3D T1 加权 MR 图像。在 MR 图像上追踪边缘系统的结构（即海马、杏仁核、前丘脑、下丘脑、乳头体、基底前脑、间隔区和扣带回、眶额皮质和海马旁皮质），并转移到配准的 SPET 扫描中。相对于小脑灌注计算所有边缘区域的灌注比率。一般线性模型多变量分析显示，总体而言，边缘结构表现出明显的低灌注（F=7.802，P
The goal of this study was to perform a systematic, semi-quantitative analysis of limbic perfusion in patients with Alzheimer's disease (AD) using coregistered single-photon emission tomography (SPET) images aligned to magnetic resonance (MR) images. Limbic perfusion in 40 patients with mild to moderate AD was compared with that of 17 age-, sex-, and education-matched normal controls (NC). HMPAO SPET scans and 3D T1-weighted MR images were acquired for each subject. Structures of the limbic system (i.e. hippocampus, amygdala, anterior thalamus, hypothalamus, mamillary bodies, basal forebrain, septal area and cingulate, orbito-frontal and parahippocampal cortices) were traced on the MR images and transferred to the coregistered SPET scans. Perfusion ratios for all limbic regions were calculated relative to cerebellar perfusion. General linear model multivariate analysis revealed that, overall, limbic structures showed significant hypoperfusion (F=7.802, P