Minimal Model of Cellular Symmetry Breaking
Minimal Model of Cellular Symmetry Breaking
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DOI：
10.1103/physrevlett.123.188101
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发表时间：
2019-10-28
影响因子：
8.6
通讯作者：
Juelicher, Frank
中科院分区：
文献类型：
--
作者：
Mietke, Alexander;Jemseena, V;Juelicher, Frank
细胞皮层是一种聚集在细胞膜下的活性物质薄膜，在细胞极性建立和细胞分裂等细胞对称性破坏过程中起着关键作用。在这里，我们提出了一个最小模型的自组织的细胞皮层，是基于流体力学理论的弯曲的活动表面。该表面上的主动应力由扩散的分子种类调节。我们表明，主动表面与被动体积流体的耦合使自发极化和通过机械化学不稳定性在表面上形成收缩环成为可能。我们讨论了外场在引导这种模式形成中的作用。我们的工作揭示了细胞对称性破坏和细胞分裂的关键特征可以通过一般动态不稳定性在最小模型中出现。
The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry-breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the self-organization of the cell cortex that is based on a hydrodynamic theory of curved active surfaces. Active stresses on this surface are regulated by a diffusing molecular species. We show that coupling of the active surface to a passive bulk fluid enables spontaneous polarization and the formation of a contractile ring on the surface via mechanochemical instabilities. We discuss the role of external fields in guiding such pattern formation. Our work reveals that key features of cellular symmetry breaking and cell division can emerge in a minimal model via general dynamic instabilities.