Clinical research at a crossroads: The NIH roadmap
Clinical research at a crossroads: The NIH roadmap
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DOI：
10.2310/6650.2006.x0016
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发表时间：
2006-05-01
影响因子：
2.6
通讯作者：
Zerhouni, Elias A.
中科院分区：
文献类型：
--
作者：
Zerhouni, Elias A.
由于NIH对生物医学研究的投资，在过去的30年里，我们看到了许多影响我们国家健康的重大进步，这些进步是通过科学进步的有效转化而促进的。然而，研究和医疗成本的上升意味着NIH必须做出战略决策，使其投资回报最大化。由于治疗终末期疾病的成本无论是个人还是经济上都是如此之高，学习如何通过分子知识和行为干预来预防疾病是未来几年维护国家健康的唯一可行战略。为了加快科学发现并将其有效地转化为患者护理，美国国立卫生研究院制定了生物医学研究路线图。路线图为资助创新项目提供了孵化器空间，以应对一系列科学挑战，并在寻求新的合作途径的研究人员之间催生了一种新的合作文化。路线图的一个重要特点是临床和翻译科学奖(CTSA)。该计划的目标是消除临床研究和基础研究之间日益增长的障碍，解决进行临床研究所涉及的日益复杂的问题，并帮助全国的机构创建临床和翻译科学的学术家园。通过现在采用强大的战略愿景，NIH将能够在未来的挑战和机遇出现时做好准备。为了与我们的使命保持一致，NIH目前和未来的行动将由科学界的要求和国家的公共卫生需求来定义。
As a result of the NIH investment in biomedical research, over the past 30 years we have seen many great advances impacting the health of our nation which have been fostered by the effective translation of scientific advances. However, rising costs for both research and health care mean that the NIH must make strategic decisions that maximize the return on its investment. Because treating end-stage disease is so costly, both personally and financially, learning how to pre-empt illness through molecular knowledge and behavioral interventions is the only viable strategy for maintaining the nation's health in the coming years.In order to speed scientific discovery and its efficient translation to patient care, the NIH developed the Roadmap for Biomedical Research. The Roadmap provides an incubator space for funding innovative programs to address a panoply of scientific challenges and has engendered a new culture of cooperation among researchers seeking new avenues for collaboration. An important feature of the Roadmap is the Clinical and Translational Science Awards (CTSA). The program's goals are to eliminate growing barriers between clinical and basic research, to address the increasing complexities involved in conducting clinical research, and to help institutions nationwide create an academic home for clinical and translational science.By adopting a strong strategic vision now, the NIH will be able to stand at the ready as future challenges and opportunities emerge. In keeping with our mission, the NIH's current and future actions will be defined by the requirements of the scientific community and the public health needs of the nation.