Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration
Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration
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DOI：
10.1016/j.cca.2011.09.023
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发表时间：
2012-01-18
影响因子：
5
通讯作者：
Yamazaki, Kazuhisa
中科院分区：
文献类型：
--
作者：
Miyazawa, Haruna;Honda, Tomoyuki;Yamazaki, Kazuhisa
背景：牙周病增加动脉粥样硬化性血栓性疾病的风险，高浓度的低密度脂蛋白(LDL)胆固醇被认为与其有关：然而，其潜在的机制在很大程度上是未知的。最近的研究表明，枯草杆菌前蛋白转换酶9(PCSK9)在循环中的低密度脂蛋白浓度中起着关键作用。本研究的目的是分析牙周炎患者血清PCSK9浓度及其与脂蛋白浓度的关系。方法：采集40例牙周炎患者和30例正常对照的血清。用酶联免疫吸附试验检测血清PCSK9、超敏C反应蛋白(hs-CRP)、IL-6、肿瘤坏死因子-α(TNF-α)和牙龈卟啉单胞菌抗体，并用商品化实验室进行血脂谱检测。结果：牙周炎患者血清抗Pggis抗体滴度和hs-CRP水平明显高于对照组，提示牙周炎患者存在牙周感染和全身炎症反应。牙周炎患者的PCSK9浓度显著高于对照组。然而，牙周炎患者和对照组的总胆固醇和低密度脂蛋白浓度没有显著差异。结论：牙周感染可上调PCSK9的生成。然而，需要进一步的研究来阐明牙周感染是如何影响PCSK9浓度和随后的脂代谢的。(C)2011爱思唯尔B.V.保留所有权利。
Background: Periodontal disease increases the risk of atherothrombotic disease, and high concentrations of low density lipoprotein (LDL) cholesterol are considered to be involved: however, the underlying mechanisms are largely unknown. Recent studies demonstrated that proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in circulating LDL cholesterol concentrations. The aim of the present study is to analyze serum PCSK9 concentrations and their relation to lipoprotein concentrations in periodontitis patients.Methods: Sera were obtained from 40 periodontitis patients and 30 control subjects. PCSK9 concentrations, high-sensitivity C-reactive protein (hs-CRP), IL-6, TNF-alpha and Porphyromonas gingivalis antibodies were measured by ELISA, and lipid profiles were determined by a commercial laboratory.Results: Periodontitis patients demonstrated significantly higher serum antibody titer to P. gingivalis and hs-CRP concentrations than control subjects, suggesting infection with P. gingivalis and a systemic inflammatory response. PCSK9 concentrations in periodontitis patients were significantly higher than those in control subjects. However, the concentrations of total and LDL cholesterols were not significantly different between periodontitis patients and control subjects. Moreover, no correlations were observed between PCSK9 concentrations and lipid profiles.Conclusion: Periodontal infection upregulates PCSK9 production. However, further studies are required to elucidate how periodontal infection affects PCSK9 concentrations and subsequent lipid metabolism. (C) 2011 Elsevier B.V. All rights reserved.