Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity
Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity
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DOI：
10.1007/s12263-014-0416-4
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发表时间：
2014-09-01
影响因子：
3.5
通讯作者：
Higuchi, Mitsuru
中科院分区：
文献类型：
--
作者：
Tanisawa, Kumpei;Ito, Tomoko;Higuchi, Mitsuru
全基因组关联研究在中年人群中发现了与体重指数(BMI)相关的单核苷酸多态(SNPs)；然而，目前尚不清楚这些SNPs是否与老年人的身体肥胖有关。我们研究了来自BMI相关SNPs的遗传风险评分(GRS)与日本老年男性体脂之间的关系。我们还研究了不同年龄段的GRS、膳食常量营养素摄入量和体力活动对身体肥胖的贡献。从84名中年(30-岁)和97名老年(65-79岁)日本男性的10个与体重指数相关的SNPs计算GRS；受试者被分为低、中、高GRS组。膳食中的常量营养素摄入量使用问卷进行评估，体力活动使用问卷和加速度计进行评估。GRS高的中年个体的BMI、腰围、腹脂、内脏脂肪和皮下脂肪面积均大于GRS低的中年个体，而老年GRS组之间上述指标无明显差异。多元线性回归分析显示，在中年组中，GRS对BMI、腹部总脂肪和内脏脂肪的预测作用最强，而脂肪、酒精和蛋白质摄入量或高强度体力活动与这些指标的相关性在老年组中比GRS更强。这些结果表明，来自BMI相关SNPs的GRS不能预测日本老年男性的身体肥胖。膳食中大量营养素的摄入和体力活动对身体肥胖的较大贡献可能会减弱老年男性的遗传易感性。
Genome-wide association studies identified single nucleotide polymorphisms (SNPs) associated with body mass index (BMI) in middle-aged populations; however, it is unclear whether these SNPs are associated with body fatness in elderly people. We examined the association between genetic risk score (GRS) from BMI-associated SNPs and body fatness in elderly Japanese men. We also examined the contribution of GRS, dietary macronutrient intake, and physical activity to body fatness by different age groups. GRS was calculated from 10 BMI-associated SNPs in 84 middle-aged (30-64 years) and 97 elderly (65-79 years) Japanese men; subjects were divided into low, middle, and high GRS groups. Dietary macronutrient intake was assessed using a questionnaire, and physical activity was evaluated using both a questionnaire and an accelerometer. The middle-aged individuals with a high GRS had greater BMI; waist circumference; and total abdominal fat, visceral fat, and subcutaneous fat areas than the middle-aged individuals with low GRS, whereas the indicators were not different between the GRS groups in elderly individuals. Multiple linear regression analysis showed that GRS was the strongest predictor of BMI, total abdominal fat, and visceral fat in the middle-aged group, whereas fat, alcohol, and protein intakes or vigorous-intensity physical activity were more strongly associated with these indicators than was GRS in the elderly group. These results suggest that GRS from BMI-associated SNPs is not predictive of body fatness in elderly Japanese men. The stronger contribution of dietary macronutrient intake and physical activity to body fatness may attenuate the genetic predisposition in elderly men.