A spatiotemporal meta-analysis of HIV/syphilis epidemic among men who have sex with men living in mainland China
A spatiotemporal meta-analysis of HIV/syphilis epidemic among men who have sex with men living in mainland China
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DOI：
10.1186/s12879-018-3532-8
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发表时间：
2018-12-12
影响因子：
3.7
通讯作者：
Tang, Weiming
中科院分区：
文献类型：
--
作者：
Fu, Rong;Zhao, Jinkou;Tang, Weiming
背景中国地区男男性接触者艾滋病、梅毒和无避孕套性行为的地理差异尚不清楚。我们的目的是阐明这些时空变化模式。方法我们进行了时空元分析。我们在四个数据库中搜索了2001至2015年间进行的研究。我们纳入了报道中国原始艾滋病毒/梅毒流行数据的研究，研究的地区/省份和数据收集的时间。我们将研究分成六个地区和四个时间段。结果共检索到2119篇文献，272篇进入Meta分析。这些研究的样本量从19到47,231不等。全国艾滋病毒感染率从2001-07年度的3.8%(95%可信区间3.0-4.8)上升到2013-15年度的6.6%(5.6-7.7)。在大多数地区，艾滋病毒流行率在2010年前上升，之后保持相对稳定，但西北地区自2008年以来出现了相当大的增长。全国梅毒感染率由2001-07年度的12.3%(10.2-14.9)下降到2013-15年度的7.1%(5.6-8.9)。结论中国地区大部分地区男男性接触者的HIV和梅毒感染趋势得到有效控制。需要继续努力，特别是推广使用避孕套，以进一步减少这些感染。
BackgroundGeographic differences in HIV, syphilis and condomless sex among men who have sex with men in China remained unknown. We aimed to elucidate these spatiotemporal changing patterns in China.MethodsWe conducted a spatiotemporal meta-analysis. We searched four databases for studies conducted between 2001 and 2015. We included studies that reported original data of HIV/syphilis prevalence in China, the study's area/province, and period of data collection. We grouped studies into six regions and four time periods. We examined the changing patterns of national and regional prevalence of HIV, syphilis and condomless sex.ResultsSearch results yielded 2119 papers, and 272 were included in the meta-analysis. The sample sizes of the studies ranged from 19 to 47,231. National HIV prevalence increased from 3.8% (95% CI 3.0-4.8) in 2001-07 to 6.6% (5.6-7.7) in 2013-15. In most regions, the rise occurred before 2010 and the HIV prevalence remained relatively stable afterwards, except for the Northwest which showed a considerable increase since 2008. National syphilis prevalence decreased from 12.3% (10.2-14.9) in 2001-07 to 7.1% (5.6-8.9) in 2013-15.ConclusionsThe trends of HIV and syphilis infections have been effectively curbed in MSM in most regions of China. Continuous efforts, particularly promotion of condom use, are needed to further reduce these infections.