B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.
B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.
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DOI：
10.7314/apjcp.2013.14.7.4301
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发表时间：
2013-07
期刊：
影响因子：
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通讯作者：
Qiong Li;Jun Yin;Xu Wang;Li-ming Wang;Yijun Shi;Liang Zheng;Weifeng Tang;G. Ding;Chao Liu;Ruiping Liu;H. Gu;Jia-Ming Sun;Suocheng Chen
中科院分区：
文献类型：
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作者：
Qiong Li;Jun Yin;Xu Wang;Li-ming Wang;Yijun Shi;Liang Zheng;Weifeng Tang;G. Ding;Chao Liu;Ruiping Liu;H. Gu;Jia-Ming Sun;Suocheng Chen
目的细胞凋亡被认为是肿瘤发生的重要组成部分，相关遗传因素在贲门腺癌的发生中起重要作用。方法我们进行了一项以医院为基础的病例对照研究，以评估功能性单核苷酸多态性（SNPs）：BCL 2 rs 17757541 C>G、BCL 2 rs 12454712 T>C、FAS rs 2234767 G>A、FASL/FASLG rs763110 C>T、ERBB 2 rs 1136201 A>G和VEGFR 2/KDR rs 11941492 C>T对GCA发生的遗传效应。研究共招募了243例GCA病例和476例对照，并使用定制设计的48-SNP scanTM试剂盒确定基因型。结果BCL 2基因rs 17757541 C>G多态性与GCA的发病风险相关。然而，与其他五个SNP没有显着关联。分层分析表明，在男性、老年患者和有吸烟或饮酒史的患者中，与BCL 2 rs 17757541 C>G多态性相关的GCA风险显著增加。结论BCL 2基因rs 17757541 C>G多态性可能与GCA易感性有关。然而，我们的结果受到样本量小的限制。未来需要更大规模的研究来证实我们目前的发现。
AIM Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis. METHODS We conducted a hospital based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscanTM Kit. RESULTS The BCL2 rs17757541 C>G polymorphism was associated with increased risk of GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicated a significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males, older patients and those with a history of smoking or drinking. CONCLUSION These findings indicated that the functional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our results were limited by small sample size. Future larger studies are required to confirm our current findings.