Combination of low-dose total skin electron beam therapy and subsequent localized skin electron beam therapy as a therapeutic option for advanced-stage mycosis fungoides.
Combination of low-dose total skin electron beam therapy and subsequent localized skin electron beam therapy as a therapeutic option for advanced-stage mycosis fungoides.
复制标题
低剂量全皮肤电子束治疗和随后的局部皮肤电子束治疗相结合，作为晚期蕈样肉芽肿的治疗选择。
DOI：
10.1111/ced.13347
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发表时间：
2018
影响因子：
4.1
通讯作者：
Funakoshi,T
中科院分区：
文献类型：
--
作者：
Kinoshita-Ise,M;Ouchi,T;Izumi,E;Kawaguchi,O;Nagao,K;Amagai,M;Funakoshi,T
电子束治疗（EBT）是蕈样肉芽肿（MF）的一种既定治疗方法，但在晚期皮肤病中使用EBT的证据有限，此类疾病的最佳治疗方案仍不清楚。我们报告的情况下，44岁的妇女诊断为MF与广泛的皮肤病变，包括多个巨大的肿瘤在颅面区。低剂量全皮肤（TS）EBT和随后的局部皮肤（LS）EBT在出疹方面取得了显著改善。治疗期间还给予口服依曲替酸。我们的经验表明，TSEBT和LSEBT相结合可能是值得尝试的，当患者同时存在广泛的病变和突出的肿瘤，即使肿瘤非常大。
Electron beam therapy (EBT) is an established treatment for mycosis fungoides (MF), but evidence for the use of EBT in advanced cutaneous conditions is limited, and optimal scheduling of the regimen for such conditions remains unclear. We report the case of a 44‐year‐old woman diagnosed with MF with widespread cutaneous lesions, including multiple huge tumours in the craniofacial area. Low‐dose total skin (TS)EBT and subsequent localized skin (LS)EBT achieved striking improvements in eruptions. Oral etretinate was also administered during therapy. Our experience implies that combined TSEBT and LSEBT may be worth attempting when a patient presents with both widespread lesions and prominent tumours, even when the tumours are extremely large.