Factors involved in cancer metastasis: a better understanding to "seed and soil" hypothesis.
Factors involved in cancer metastasis: a better understanding to "seed and soil" hypothesis.
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癌症转移相关因素：更好地理解“种子和土壤”假说
DOI：
10.1186/s12943-017-0742-4
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发表时间：
2017-12-02
期刊：
影响因子：
37.3
通讯作者：
Luo D
中科院分区：
文献类型：
--
作者：
Liu Q;Zhang H;Jiang X;Qian C;Liu Z;Luo D
100多年来，转移一直吸引着研究人员。尽管技术和治疗策略的发展，转移仍然是癌症相关死亡的主要原因，直到今天。著名的“种子和土壤”假说被广泛引用和接受，直到今天它仍然为癌症研究提供了重要的指导。据我们所知，有几个全面和相关的审查，集中在种子和土壤因素参与癌症转移;此外，尽管事实上，越来越多的潜在机制和概念已被定义最近，以前的观点是有吸引力的，但可能是有限的。因此，我们回顾了参与癌症转移的因素，包括种子和土壤因素。通过将新概念与经典假说相结合，我们的目标是提供对“种子和土壤”假说的全面理解，并概念化理解癌症转移相关因素的框架。基于对这一领域的动态概述，我们还讨论了未来研究和临床治疗策略的潜在影响。
Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The famous “seed and soil” hypothesis is widely cited and accepted, and it still provides significant instructions in cancer research until today. To our knowledge, there are few reviews that comprehensively and correlatively focus on both the seed and soil factors involved in cancer metastasis; moreover, despite the fact that increasingly underlying mechanisms and concepts have been defined recently, previous perspectives are appealing but may be limited. Hence, we reviewed factors involved in cancer metastasis, including both seed and soil factors. By integrating new concepts with the classic hypothesis, we aim to provide a comprehensive understanding of the “seed and soil” hypothesis and to conceptualize the framework for understanding factors involved in cancer metastasis. Based on a dynamic overview of this field, we also discuss potential implications for future research and clinical therapeutic strategies.
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