Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
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DOI：
10.1039/c1cc14824a
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Yao, Shao Q.
中科院分区：
文献类型：
--
作者：
Shi, Haibin;Cheng, Xiamin;Yao, Shao Q.
合成了一种可点击的、基于亲和力的探针 (Af BP)，该探针由星形孢菌素（一种天然产物激酶抑制剂）修饰而成，并可原位用于对 HepG2 癌细胞中星形孢菌素的潜在细胞靶标进行基于活性的蛋白质组分析。
A clickable, affinity-based probe (Af BP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.