Morbidity of Chagas disease among autochthonous patients from the Rio Negro microregion, State of Amazonas
Morbidity of Chagas disease among autochthonous patients from the Rio Negro microregion, State of Amazonas
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DOI：
10.1590/s0037-86822010000200013
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发表时间：
2010-03-01
影响因子：
2
通讯作者：
Coura, Jose Rodrigues
中科院分区：
文献类型：
--
作者：
Brum-Soares, Lucia Maria;Xavier, Sergio Salles;Coura, Jose Rodrigues
导论.对生活在亚马孙州Bagos区的152名土著人进行了一项血清流行病学和临床研究，以评估南美锥虫病感染的血清阳性率和发病率。方法.使用的血清学试验是间接免疫荧光、常规和重组ELISA和免疫印迹（Tesa-blot）。38例患者被认为是血清阳性; 31例被认为是血清阳性; 83例被认为是血清阴性。38例血清阳性病例与38例相同年龄和性别的血清阴性对照配对，并进行流行病学和临床评估，心电图和超声心动图。二十九对接受了食道放射学检查。结果血清阳性是19.9倍更频繁的工人收集植物材料的森林和10.4倍更频繁的皮亚萨巴采集者。86.7%的血清阳性个体将Rhodnius属识别为当地媒介，而血清阴性个体仅34.2%识别出这一点。心电图异常的36.8%的血清阳性的个人和21.5%的血清阴性的个人，而超声心动图显示异常的31.6%的血清阳性和18.4%的血清阴性的个人。心前区疼痛和心悸在血清阳性个体中更常见。消化系统的临床评价和食管X线检查未显示明显异常。结论.研究区域的恰加斯病可被视为一种职业病。
Introduction. A seroepidemiological and clinical study was conducted on 152 autochthonous individuals living in the district of Barcelos, State of Amazonas, to evaluate the seroprevalence of Chagas infection and morbidity of Chagas disease. Methods. The serological tests used were indirect immunofluorescence, conventional and recombinant ELISA and immunoblot (Tesa-blot). Thirty-eight patients were considered seropositive; 31 were considered serodoubtful; and 83 were considered seronegative. The 38 seropositive cases were paired with 38 seronegative controls of the same age and sex, and underwent epidemiological and clinical evaluations, electrocardiograms and echocardiograms. Twenty-nine pairs underwent radiological examinations of the esophagus. Results. Seropositivity was 19.9 times more frequent among workers gathering plant materials from the forests and 10.4 times more frequent among piassaba gatherers. Eighty six point seven percent of the seropositive individuals recognized the genus Rhodnius as the local vector, while only 34.2% of the seronegative individuals recognized this. The EKG was abnormal in 36.8% of the seropositive individuals and in 21.5% of the seronegative individuals, while the echocardiogram showed abnormalities in 31.6% of the seropositive and 18.4% of the seronegative individuals. Precordialgia and palpitation were more frequent among the seropositive individuals. Clinical evaluation on the digestive system and X-ray on the esophagus did not show significant abnormalities. Conclusions. Chagas disease in the study region can be considered to be an occupational disease.