Oxidative stress: relations between the formation of reactive species and the organism's defense
Oxidative stress: relations between the formation of reactive species and the organism's defense
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DOI：
10.1590/s0100-40422006000100021
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发表时间：
2006-02-01
期刊：
影响因子：
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通讯作者：
David, Juceni P.
中科院分区：
文献类型：
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作者：
Barreiros, André L. B. S.;David, Jorge M.;David, Juceni P.
本工作描述了活性氧（ROS）和活性氮（RNS）在人体氧化应激中的作用机制，以及它们对DNA、RNA、蛋白质和脂质的损伤后果。它还说明了我们的生物体对这些ROS和RNS物种的防御系统。非酶保护系统的行动报告，重点是小分子，如Q10辅酶，维生素C，α-生育酚，类胡萝卜素和类黄酮。强调了黄酮类化合物的重要性，并详细介绍了其对机体的保护机制。
This work describes the mechanism of action of some reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the oxidative stress of the human body, and their consequences on damage to DNA, RNA, proteins and lipids. It also illustrates the defense system of our organism against these ROS and RNS species. The action of nonenzymatic protection systems is reported, with emphasis on micromolecules like Q10 coenzyme, vitamin C, a-tocopherol, carotenoids and flavonoids. The importance of flavonoids is also emphasized, and their body protection mechanism is detailed.