Gender and alcohol moderate prenatal cocaine effects on teacher-report of child behavior
Gender and alcohol moderate prenatal cocaine effects on teacher-report of child behavior
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DOI：
10.1016/j.ntt.2004.10.004
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发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Delaney-Black, V
中科院分区：
文献类型：
--
作者：
Bailey, BN;Sood, BG;Delaney-Black, V
产前接触可卡因与学龄期行为问题有关。然而，怀孕期间使用可卡因和酒精之间的对应性通常很高，这使得对其他暴露及其相互作用进行适当的方差分配和控制变得困难。此外，通常不会报告特定性别的影响。本研究的目的是确定在评估产前酒精暴露时，产前可卡因暴露对教师报告的儿童外化行为问题的性别特异性影响的明显程度。受试者是在怀孕期间接受前瞻性评估的母亲的单胎婴儿。 7 岁时，我们的实验室对 499 名儿童（其中 214 名在产前接触过可卡因）进行了评估，并征求了教师报告。按性别和产前酒精暴露状况进行分层分析，并控制显着的产前和产后混杂因素，结果显示，在产前酒精暴露的男孩中，与没有接触可卡因的男孩相比，在整个怀孕期间持续接触可卡因的男孩的犯罪行为水平显着更高。产前接触过可卡因的男孩获得具有临床意义的外化行为评分的可能性是未接触过可卡因的男孩的两倍。然而，对于没有产前酒精暴露的男孩，未发现产前可卡因暴露与外化行为评分和特定综合征之间存在关联。在产前没有接触过酒精的女孩中，在控制混杂因素后，与没有产前接触过可卡因的女孩相比，那些持续接触可卡因的女孩的外化行为和攻击性行为水平显着更高，并且具有临床显着性外化行为评分的可能性几乎是其五倍。然而，对于产前酒精暴露的女孩，在控制混杂因素后，未发现产前可卡因暴露与外化行为和特定综合征得分之间存在关联。目前的研究结果支持性别和酒精调节产前接触可卡因对学龄教师报告的儿童行为问题的影响。这些发现与我们报告的独立家长报告的行为评估相似。 (c) 2004 Elsevier Inc. 保留所有权利。
Prenatal cocaine exposure has been associated with behavior problems at school age. However, the correspondence between use of cocaine and alcohol during pregnancy is often high, making appropriate allocation of variance and control for other exposures and their interactions difficult. Additionally, gender-specific effects are not typically reported. The purpose of the current study was to determine the degree to which gender-specific effects of prenatal cocaine exposure on teacher-reported child externalizing behavior problems were evident when evaluated in relation to prenatal alcohol exposure. Subjects were singleton infants of mothers who were prospectively evaluated during pregnancy. At age seven, 499 children (214 exposed prenatally to cocaine) were evaluated in our laboratory and teacher reports were solicited. Analyses stratified by gender and prenatal alcohol exposure status, and controlled for significant pre- and postnatal confounders, revealed that among boys with prenatal alcohol exposure, those with persistent cocaine exposure throughout pregnancy had significantly higher levels of Delinquent Behavior compared to boys with no cocaine exposure. Boys with any prenatal cocaine exposure were twice as likely as unexposed boys to have clinically significant Externalizing Behavior scores. However, no association was found between prenatal cocaine exposure and scores on Externalizing Behavior and specific syndromes for boys with no prenatal alcohol exposure. Among girls with no prenatal alcohol exposure, those with persistent cocaine exposure had significantly higher levels of Externalizing Behaviors and Aggressive Behaviors compared to girls with no prenatal cocaine exposure after control for confounding, and were almost five times as likely to have clinically significant Externalizing Behavior scores. However, for girls with prenatal alcohol exposure, no association between prenatal cocaine exposure and scores on Externalizing Behavior and specific syndromes was found after control for confounding. The current findings support gender- and alcohol-moderated effects of prenatal cocaine exposure on school-age teacher-reported child behavior problems. These findings are similar to what we have reported for independent parent-reported behavioral evaluation. (c) 2004 Elsevier Inc. All rights reserved.