Inheritance of Resistance to Permethrin and DDT in the Southern House Mosquito (Diptera: Culicidae)
Inheritance of Resistance to Permethrin and DDT in the Southern House Mosquito (Diptera: Culicidae)
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南方家蚊（双翅目：蚊科）对氯菊酯和滴滴涕的抗性遗传
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
G. Georghiou
中科院分区：
文献类型：
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作者：
W. Halliday;G. Georghiou
使用通过氯菊酯实验室筛选获得的高抗性菌落，研究了致倦库蚊对氯菊酯和滴滴涕的抗性遗传学。当测试与拟除虫菊酯抗性菌株回交的后代时，概率回归出现平台期。因此，对氯菊酯的抗性被隔离，就好像只有一个主基因一样。对滴滴涕的抗性遗传受到其他因素的强烈影响，因为没有看到类似的平台期。当滴滴涕与脱氢氯酸酶抑制剂氯芬醇一起使用时，滴滴涕抗性根据单一主要隐性基因的预期进行分离。无论混合功能氧化酶系统或脱氯化氢的解毒潜力如何，使用滴滴涕类似物的生物测定都显示出类似的高水平耐药性。因此，敲低抗性基因 kdr 被证明对氯菊酯和 DDT 类化合物的抗性有显着贡献。
The genetics of resistance to permethrin and DDT in Culex quinquefasciatus Say was investigated using a highly resistant colony obtained through laboratory selection by permethrin. A plateau in the probit regression occurred when progeny of a backcross to the pyrethroid-resistant strain were tested. Hence, resistance to permethrin segregated as if there were a single major gene. The inheritance of resistance to DDT was strongly influenced by additional factors since no similar plateau was seen. When DDT was used with the dehydrochlorinase inhibitor chlorfenethol, DDT resistance segregated according to expectations for a single major recessive gene. Bioassays with DDT analogs revealed similarly high levels of resistance regardless of differences in potential for detoxication by either the mixed function oxidase system or by dehydrochlorination. Therefore, the knockdown resistance gene, kdr , was shown to contribute significantly to resistance toward both permethrin and DDT-type compounds.