EXPRESSION OF ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN IS INCREASED IN REACTIVE AND NEOPLASTIC GLIAL-CELLS
EXPRESSION OF ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN IS INCREASED IN REACTIVE AND NEOPLASTIC GLIAL-CELLS
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DOI：
10.1016/0014-5793(94)80288-2
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发表时间：
1994-02-07
期刊：
影响因子：
3.5
通讯作者：
VANDENBERG, SR
中科院分区：
文献类型：
--
作者：
LOPES, MBS;BOGAEV, CA;VANDENBERG, SR
α（2）-巨球蛋白受体/低密度脂蛋白受体相关蛋白（α（2）M-R/LRP）是一种多功能细胞表面受体，参与多种生理过程。在正常人脑中，α（2）M-R/LRP主要由锥体神经元表达，定位于细胞体和近端突起。相比之下，α 2 M-R/LRP不存在于大多数正常大胶质细胞（包括星形胶质细胞）的细胞体或突起中。在这项研究中，我们研究了α（2）M-R/LRP在脑组织损伤或肿瘤转化，免疫组织化学的表达。在反应性星形胶质细胞中发现了显著增加的α（2）M-RILRP免疫反应性，表明该受体的表达在体内对脑损伤的反应中受到调节。在神经胶质细胞肿瘤中也检测到α（2）M-R/LRP免疫反应性;这一发现是新的，因为恶性转化通常被认为关闭了该受体的表达。
alpha(2)-Macroglobulin receptor/low density lipoprotein receptor-related protein (alpha(2)M-R/LRP) is a multi-functional cell-surface receptor that has been implicated in diverse physiologic processes. In normal human brain, alpha(2)M-R/LRP is expressed principally by pyramidal neurons with localization to cell bodies and proximal processes. By contrast, alpha(2)M-R/LRP is not present in either the cell bodies or processes of most normal macroglia (including astrocytes). In this investigation, we studied the expression of alpha(2)M-R/LRP in the brain, following tissue injury or neoplastic transformation, by immunohistochemistry. Significantly increased alpha(2)M-RILRP immunoreactivity was identified in reactive astrocytes, indicating that expression of this receptor is regulated in vivo in response to brain injury. alpha(2)M-R/LRP immunoreactivity was also detected in glial cell tumors; this finding is novel since malignant transformation is typically thought to turn off expression of this receptor.