PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice
PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice
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DOI：
10.1016/j.bmcl.2005.09.082
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发表时间：
2006-01-15
影响因子：
2.7
通讯作者：
Zheng, QH
中科院分区：
文献类型：
--
作者：
Wang, JQ;Pollok, KE;Zheng, QH
合成了新的碳 11 标记的 D-荧光素类似物 D-荧光素 [C-11] 甲酯 ([C-11]LMEster, [C-11]1) 和 D-荧光素 [C-11] 甲醚 ([C-11]LMEther, [C-11]2)，放射化学产率为 25-55%。使用 [C-11]LMEster 和 [C-11]LMEther 进行的 PET 研究表明，注射后 45 分钟，表达荧光素酶的肿瘤中 C-11 标记的保留率较低。使用未标记的底物 D-荧光素和放射性示踪剂 [C-11]LMEster 和 [C-11]LMEther 进行光学成像，在光子计数后几分钟内即可生成肿瘤荧光素酶图像。 (c) 2005 Elsevier Ltd. 保留所有权利。
New carbon-11 labeled D-luciferin analogs D-luciferin [C-11]methyl ester ([C-11]LMEster, [C-11]1) and D-luciferin [C-11]methyl ether ([C-11]LMEther, [C-11]2) were synthesized in 25-55% radiochemical yield. PET studies with [C-11]LMEster and [C-11]LMEther demonstrate a lower retention of the C-11 label at 45 min post-injection in luciferase expression tumor. Optical imaging with unlabeled substrate D-luciferin and radiotracers [C-11]LMEster and [C-11]LMEther gave tumor luciferase images within a few minutes of photon counting. (c) 2005 Elsevier Ltd. All rights reserved.