An Examination of Stroke Risk and Burden in South Asians
An Examination of Stroke Risk and Burden in South Asians
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DOI：
10.1016/j.jstrokecerebrovasdis.2017.04.036
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发表时间：
2017-10-01
影响因子：
2.5
通讯作者：
Pandian, Jeyaraj
中科院分区：
文献类型：
--
作者：
Singh, Vineeta;Prabhakaran, Shyam;Pandian, Jeyaraj
工作背景：南亚人（印度，巴基斯坦，斯里兰卡，孟加拉国，尼泊尔和不丹）由于其心脏代谢特征，中风和心脏病的风险不成比例地高。尽管有证据表明糖尿病和中风之间有很强的联系，而且在这个少数民族中中风的风险增加--尽管有报道说无论居住在哪个国家，中风的死亡率都较高--但中风风险过高的原因仍然未知。研究方法：我们使用了广泛的文献综述、流行病学研究、发病率和死亡率记录以及专家意见来研究南亚人的卒中负担以及迄今为止确定的危险因素。结果：我们总结了现有的证据，并指出在南亚本地人和移民之间的中风流行病学的现有知识的差距。结论：这项研究将注意力集中在迫在眉睫的中风流行上，这主要是由于可改变的风险因素，但也有新的决定因素可能会加剧南亚人血管风险因素的影响，导致更多致残性中风和死亡。
Background: South Asians (India, Pakistan, Sri Lanka, Bangladesh, Nepal, and Bhutan) are at a disproportionately higher risk of stroke and heart disease due to their cardiometabolic profile. Despite evidence for a strong association between diabetes and stroke, and growing stroke risk in this ethnic minority-notwithstanding reports of higher stroke mortality irrespective of country of residence-the explanation for the excess risk of stroke remains unknown. Methods: We have used extensive literature review, epidemiologic studies, morbidity and mortality records, and expert opinions to examine the burden of stroke among South Asians, and the risk factors identified thus far. Results: We summarize existing evidence and indicate gaps in current knowledge of stroke epidemiology among South Asian natives and immigrants. Conclusions: This research focuses attention on a looming epidemic of stroke mainly due to modifiable risk factors, but also new determinants that might aggravate the effect of vascular risk factors in South Asians causing more disabling strokes and death.