Equilibrium shapes of erythrocytes in rouleau formation
Equilibrium shapes of erythrocytes in rouleau formation
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DOI：
10.1016/s0006-3495(03)74961-3
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发表时间：
2003-03-01
影响因子：
3.4
通讯作者：
Zeks, B
中科院分区：
文献类型：
--
作者：
Derganc, J;Bozic, B;Zeks, B
红细胞的一个众所周知的生理特性是它们可以聚集并形成rouleau。我们提出了一个理论分析的红细胞形状在一个长rouleau组成的细胞具有相同的大小。该研究基于脂膜的面积差弹性模型，并考虑了弯曲轴对称膜的粘附。分析预测，红细胞在红细胞叠可以有一个盘状或杯状的形状。这些形状类似于游离红细胞的盘状和口细胞形状。的盘状和杯状之间的过渡形状的Rouleau的特点。这些转变的发生取决于三个模型参数：细胞的相对体积，膜双层小叶的区域之间的优选差异，以及膜之间的粘附强度。杯状形状在小的相对体积和小的优选面积差下是有利的，并且盘状形状在这些参数的大值下是有利的。增加的粘附强度扩大了细胞之间的接触面积，使细胞粘附，并因此促进了盘状形状。
A well known physiological property of erythrocytes is that they can aggregate and form a rouleau. We present a theoretical analysis of erythrocyte shapes in a long rouleau composed of cells with identical sizes. The study is based on the area difference elasticity model of lipid membranes, and takes into consideration the adhesion of curved axisymmetric membranes. The analysis predicts that the erythrocytes in the rouleau can have either a discoid or a cup-like shape. These shapes are analogous to the discoid and stomatocyte shapes of free erythrocytes. The transitions between the discoid and cuplike shapes in the rouleau are characterized. The occurrence of these transitions depends on three model parameters: the cell relative volume, the preferred difference between the areas of the membrane bilayer leaflets, and the strength of the adhesion between the membranes. The cup-like shapes are favored at small relative volumes and small preferred area differences, and the discoid shapes are favored at large values of these parameters. Increased adhesion strength enlarges the contact area between the cells, flattens the cells, and consequently promotes the discoid shapes.