SEX AND THE SINGLE KIDNEY
SEX AND THE SINGLE KIDNEY
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DOI：
10.1016/s0272-6386(89)80035-6
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发表时间：
1989-04-01
影响因子：
13.2
通讯作者：
WILSON, CB
中科院分区：
文献类型：
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作者：
BAYLIS, C;WILSON, CB
显微穿刺测量结果显示，单肾切除术后约9至10个月，维持高蛋白饮食，肾小球毛细血管血压显着高于雄性大鼠比处女雌性大鼠。这可能解释了其他人报告的男性对年龄和消融诱导的肾小球损伤的更大易感性，尽管在本研究时，男性与女性的功能显著降低和肾小球硬化恶化几乎不明显。在第二组慢性单侧肾切除雌性动物中，研究了多次（5次）连续妊娠和哺乳的影响，在该潜在肾损害模型中，未显示妊娠对肾小球的任何严重有害长期影响。在每组中观察到对急性静脉内甘氨酸激发的可变反应，其与肾小球损伤的程度没有很好的相关性，这表明该试验可能并不总是关于潜在肾小球疾病的信息。
Micropuncture measurements revealed that approximately 9 to 10 months after uninephrectomy and maintenance on a high-protein diet, glomerular capillary BP was significantly higher in male than in virgin female rats. This might account for the greater susceptibility of the male to age- and ablation-induced glomerular damage reported by others, although at the time of the present studies, significant reduction in function and worsening in glomerulosclerosis in malesvfemales was barely evident. In a second group of chronically uninephrectomized females, the effects of multiple (five) consecutive pregnancies and lactations were investigated and did not indicate any severe deleterious long-term effects of pregnancy on the glomeruli in this model of underlying renal compromise. Variable responses to an acute intravenous glycine challenge which did not correlate well with the extent of glomerular damage were observed in each group, suggesting that this test may not always be informative regarding underlying glomerular disease.